Microbial signals in primary and metastatic brain tumors.

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Bibliographic Details
Title: Microbial signals in primary and metastatic brain tumors.
Authors: Morad G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. gmorad@mdanderson.org., Damania AV; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Melendez B; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Singh BB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Veguilla FJ; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Soto RA; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hoballah YM; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sahasrabhojane PV; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wong MC; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ahmed MM; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rico RN; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lewis KN; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wani K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Shamsutdinova DD; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lazcano Segura RN; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Massachusetts General Brigham, Boston, MA, USA., Ingram DR; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Goethe EA; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA., Day A; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Flores II; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., McDaniel LK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Chelvanambi M; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Johnson SB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dimitriou F; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gupta P; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Cancer Biology, Mayo Clinic, Scottsdale, AZ, USA., Oberai S; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zal MA; Advanced Microscopy Core Facility, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Doss P; Electron Microscopy Core Facility,The University of Texas Southwestern, Dallas, TX, USA., Jamal MA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Medicine, Houston Methodist Research Institute, Houston, TX, USA., Hayase E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Wathoo C; Department of Neuro-oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Norberg LM; Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jenkins SL; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Cancer Neuroscience Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nass S; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gumin J; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Long L; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yang J; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bradley GR; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bekal MP; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Dono AG; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Pichardo-Rojas PS; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Andrewes SW; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA., Ballester LY; Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Losh JS; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liang J; Department of Neuro-oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Huo L; Department of Neuro-oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nielsen DC; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Parker Kerrigan BC; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Brastianos PK; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Fowlkes NW; Department of Veterinary Medicine and Surgery, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jenq RR; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gomez-Manzano C; Department of Neuro-oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Huse JT; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lazar AJ; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bhat KP; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Cancer Biology, Mayo Clinic, Scottsdale, AZ, USA., Tandon N; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Esquenazi Y; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Peterson CB; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Puduvalli VK; Department of Neuro-oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lang FF; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Johnston CD; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bullman S; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ajami NJ; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ferguson SD; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org.; Platform for Innovative Microbiome and Translational Research (PRIME-TR), The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org.
Source: Nature medicine [Nat Med] 2025 Nov; Vol. 31 (11), pp. 3675-3688. Date of Electronic Publication: 2025 Nov 14.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-025-03957-4