Anti-cathepsin D antibody-drug conjugates for the targeted delivery of monomethyl auristatin F and E elicit potent anticancer activity in breast cancer.

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Title: Anti-cathepsin D antibody-drug conjugates for the targeted delivery of monomethyl auristatin F and E elicit potent anticancer activity in breast cancer.
Authors: Nishimwe D; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Guillon G; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Mallavialle A; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Martin C; UMR 1100 CEPR, INSERM, University of Tours, Tours F-37200, France., Huvelle S; UMR 1100 CEPR, INSERM, University of Tours, Tours F-37200, France., Alcaraz LB; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Romero A; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Garapon C; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Garambois V; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Mansouri H; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Boissière-Michot F; Translational Research Unit, ICM, Montpellier, France., Berestjuk I; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Jarlier M; Biometry Department, ICM, Montpellier, France., Turtoi A; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France; Gunma University Initiative for Advanced Research, Maebashi, Gunma 371-0034, Japan., Denevault-Sabourin C; UMR 1100 CEPR, INSERM, University of Tours, Tours F-37200, France., Roger P; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France; Department of Pathology, CHU Nîmes, Nîmes, France., Guiu S; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France; Department of Medical Oncology, ICM, Montpellier, France., Chardès T; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France; CNRS, Centre national de la recherche Scientifique, Paris F-75016, France., Joubert N; UMR 1100 CEPR, INSERM, University of Tours, Tours F-37200, France., Laurent-Matha V; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Liaudet-Coopman E; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France. Electronic address: emmanuelle.liaudet-coopman@inserm.fr.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118775. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2025.118775