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Single-cell transcriptomics reveal circulating skin-homing CLA+ CTSW+ cytotoxic CD4+ T cells contribute to relapse of psoriasis.

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Title: Single-cell transcriptomics reveal circulating skin-homing CLA+ CTSW+ cytotoxic CD4+ T cells contribute to relapse of psoriasis.
Authors: Chiu HY; Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.; Department of Medical Research, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.; Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan., Chan KK; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Wang JR; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Bioinformatics and Systems Biology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Liao HT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Huang HN; Department of Pathology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.; Department of Pathology and Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan., Ko TM; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Bioinformatics and Systems Biology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; School of Pharmacy, College of Pharmacy, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Source: Clinical and translational medicine [Clin Transl Med] 2025 Nov; Vol. 15 (11), pp. e70518.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Single-cell transcriptomics reveal circulating skin-homing CLA<superscript>+</superscript> CTSW<superscript>+</superscript> cytotoxic CD4<superscript>+</superscript> T cells contribute to relapse of psoriasis.
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  Data: <searchLink fieldCode="AU" term="%22Chiu+HY%22">Chiu HY</searchLink>; Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.; Department of Medical Research, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.; Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chan+KK%22">Chan KK</searchLink>; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JR%22">Wang JR</searchLink>; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Bioinformatics and Systems Biology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+HT%22">Liao HT</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+HN%22">Huang HN</searchLink>; Department of Pathology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.; Department of Pathology and Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+TM%22">Ko TM</searchLink>; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Bioinformatics and Systems Biology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; School of Pharmacy, College of Pharmacy, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101597971%22">Clinical and translational medicine</searchLink> [Clin Transl Med] 2025 Nov; Vol. 15 (11), pp. e70518.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101597971 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2001-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220011326%22">20011326 </searchLink><i>NLM ISO Abbreviation: </i>Clin Transl Med <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1002/ctm2.70518
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      – Code: eng
        Text: English
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        StartPage: e70518
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      – TitleFull: Single-cell transcriptomics reveal circulating skin-homing CLA+ CTSW+ cytotoxic CD4+ T cells contribute to relapse of psoriasis.
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            NameFull: Chan KK
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            – D: 01
              M: 11
              Text: 2025 Nov
              Type: published
              Y: 2025
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              Value: 11
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            – TitleFull: Clinical and translational medicine
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