CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses.
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| Title: | CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses. |
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| Authors: | Wu Z; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Yang Z; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada.; Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China., Iftikhar T; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Groot G; Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada., Leary SC; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Baniak N; Department of Pathology, University of Saskatchewan, Saskatoon, SK, Canada., Ahmed S; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Bosch M; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Moser M; Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada., Zhang W; Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada., Jiang J; Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China. jiangjunhong1969@suda.edu.cn., Xiang J; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada. jim.xiang@usask.ca.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada. jim.xiang@usask.ca. |
| Source: | Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Nov 18; Vol. 74 (12), pp. 378. Date of Electronic Publication: 2025 Nov 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0851 |
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| DOI: | 10.1007/s00262-025-04217-7 |
