CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses.

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Title: CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses.
Authors: Wu Z; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Yang Z; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada.; Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China., Iftikhar T; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Groot G; Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada., Leary SC; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Baniak N; Department of Pathology, University of Saskatchewan, Saskatoon, SK, Canada., Ahmed S; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Bosch M; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada., Moser M; Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada., Zhang W; Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada., Jiang J; Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China. jiangjunhong1969@suda.edu.cn., Xiang J; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada. jim.xiang@usask.ca.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada. jim.xiang@usask.ca.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Nov 18; Vol. 74 (12), pp. 378. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8<superscript>+</superscript>CD103<superscript>+</superscript> cDC1 and TRM cell responses.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada.; Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Iftikhar+T%22">Iftikhar T</searchLink>; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Groot+G%22">Groot G</searchLink>; Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Leary+SC%22">Leary SC</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Baniak+N%22">Baniak N</searchLink>; Department of Pathology, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Ahmed+S%22">Ahmed S</searchLink>; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Bosch+M%22">Bosch M</searchLink>; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Moser+M%22">Moser M</searchLink>; Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China. jiangjunhong1969@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xiang+J%22">Xiang J</searchLink>; Saskatoon Cancer Center, Saskatchewan Cancer Agency, Saskatoon, SK, Canada. jim.xiang@usask.ca.; Department of Oncology, University of Saskatchewan, Saskatoon, SK, Canada. jim.xiang@usask.ca.
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  Data: <searchLink fieldCode="JN" term="%228605732%22">Cancer immunology, immunotherapy : CII</searchLink> [Cancer Immunol Immunother] 2025 Nov 18; Vol. 74 (12), pp. 378. <i>Date of Electronic Publication: </i>2025 Nov 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8605732 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0851 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203407004%22">03407004 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Immunother <i>Subsets: </i>MEDLINE
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              Text: 2025 Nov 18
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