Reliable variability in subjective responses to parenteral hydromorphone administration: empirical confirmation of an opioid non-responder phenotype.

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Title: Reliable variability in subjective responses to parenteral hydromorphone administration: empirical confirmation of an opioid non-responder phenotype.
Authors: Ellis JD; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA., Towers EB; Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, USA., Dunn KE; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA.; Kahlert Institute for Addiction Medicine, University of Maryland, Baltimore, MD, USA., Tsang S; Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, USA., Speed T; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA., Lerman SF; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA., Mei M; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA., Lynch W; Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, School of Medicine, Charlottesville, USA., Strain EC; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA., Smith MT; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA., Finan PH; Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, USA. finan@virginia.edu.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 Jan; Vol. 51 (2), pp. 455-463. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1740-634X
DOI:10.1038/s41386-025-02271-4