Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer.

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Title: Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer.
Authors: Pribyl LJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Kay JE; Silent Spring Institute, Newton, MA, 02460, USA., Corrigan JJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Volk LB; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Norales M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Owiti NA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Kowal EA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Kohale IN; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Nazari IS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Swanson MR; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Moise AC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Ma D; David H. Koch Institute for Integrative Cancer Research, Bioinformatics and Computing Facility of Swanson Biotechnology Center, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Levine SS; BioMicro Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Michelsen E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Croy RG; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Ragan T; TissueVision, Newton, MA, 02458, USA., Torous DK; Litron Laboratories, Rochester, NY, 14623, USA., Avlasevich SL; Litron Laboratories, Rochester, NY, 14623, USA., Dertinger SD; Litron Laboratories, Rochester, NY, 14623, USA., Carrasco SE; Laboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Rockefeller University, New York, NY, 10065, USA., Samson LD; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Essigmann JM; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., White FM; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Engelward BP; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 03. Date of Electronic Publication: 2025 Oct 03.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.10.01.679856