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Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.

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Title: Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.
Authors: Sim MA; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Department of Intensive Care Medicine, Ng Teng Fong General Hospital, and Department of Anaesthesia, National University Hospital, National University Heath System, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg., Tham YC; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. thamyc@nus.edu.sg.; Center for Innovation and Precision Eye Health; and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. thamyc@nus.edu.sg.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore General Hospital, Singapore, Singapore. thamyc@nus.edu.sg., Tan ESJ; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore., Chong JR; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chai YL; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chan SP; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.; Centre for Behavioral & Implementation Science Interventions, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chua J; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore General Hospital, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Yuan VC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Wu L; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Liew OW; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore., Chong JPC; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore., Ng JYX; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore., Tan BY; St Luke's Hospital, Singapore, Singapore., Venketasubramanian N; Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore., Hilal S; Saw Swee Hock School for Public Health, National University of Singapore, Singapore, Singapore., Schmetterer L; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore General Hospital, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Choi HW; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, National University of Singapore, Singapore, Singapore., Ling LH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore., Richards AM; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.; Christchurch Heart Institute, University of Otago, Dunedin, New Zealand., Lai MKP; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chen CLH; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore. cchen@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. cchen@nus.edu.sg.
Source: Communications medicine [Commun Med (Lond)] 2025 Nov 15; Vol. 5 (1), pp. 511. Date of Electronic Publication: 2025 Nov 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918250414506676 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-664X (Electronic) Linking ISSN: 2730664X NLM ISO Abbreviation: Commun Med (Lond) Subsets: PubMed not MEDLINE
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  Data: Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.
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  Data: <searchLink fieldCode="AU" term="%22Sim+MA%22">Sim MA</searchLink>; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Department of Intensive Care Medicine, Ng Teng Fong General Hospital, and Department of Anaesthesia, National University Hospital, National University Heath System, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.<br /><searchLink fieldCode="AU" term="%22Tham+YC%22">Tham YC</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. thamyc@nus.edu.sg.; Center for Innovation and Precision Eye Health; and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. thamyc@nus.edu.sg.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore General Hospital, Singapore, Singapore. thamyc@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Tan+ESJ%22">Tan ESJ</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+JR%22">Chong JR</searchLink>; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chai+YL%22">Chai YL</searchLink>; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+SP%22">Chan SP</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.; Centre for Behavioral & Implementation Science Interventions, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chua+J%22">Chua J</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore General Hospital, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yuan+VC%22">Yuan VC</searchLink>; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Liew+OW%22">Liew OW</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+JPC%22">Chong JPC</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+JYX%22">Ng JYX</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+BY%22">Tan BY</searchLink>; St Luke's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Venketasubramanian+N%22">Venketasubramanian N</searchLink>; Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hilal+S%22">Hilal S</searchLink>; Saw Swee Hock School for Public Health, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Schmetterer+L%22">Schmetterer L</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore General Hospital, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Choi+HW%22">Choi HW</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ling+LH%22">Ling LH</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Richards+AM%22">Richards AM</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Heart Centre, Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.; Christchurch Heart Institute, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lai+MKP%22">Lai MKP</searchLink>; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+CLH%22">Chen CLH</searchLink>; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore. cchen@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. cchen@nus.edu.sg.
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