Engineered chimeric T7 RNA polymerase improves salt tolerance and reduces dsRNA impurity generation during in vitro transcription of mRNA.
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| Title: | Engineered chimeric T7 RNA polymerase improves salt tolerance and reduces dsRNA impurity generation during in vitro transcription of mRNA. |
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| Authors: | Sanjeev A; Verve Therapeutics, Boston, MA 02215, United States.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States., Summers CR; Verve Therapeutics, Boston, MA 02215, United States., Politi J; Verve Therapeutics, Boston, MA 02215, United States., Beuning PJ; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States., Cheng CJ; Verve Therapeutics, Boston, MA 02215, United States. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2025 Nov 13; Vol. 53 (21). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkaf1124 |
