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Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery.

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Title: Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery.
Authors: Chen TY; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 11031, Taiwan., Chang CY; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Xu L; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Wen TC; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Lin YH; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Peng CL; Department of Isotope Application Research, National Atomic Research Institute, Taoyuan, 325207, Taiwan., Yeh YQ; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, 30076, Taiwan., Chen CH; Research Center for Applied Science, Academia Sinica, Taipei, 115201, Taiwan., Tsai IL; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: isabel10@tmu.edu.tw., Chuang KH; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 11031, Taiwan; PhD Program in Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: khchuang@tmu.edu.tw., Wu SH; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: smilehanwu@tmu.edu.tw.
Source: Biomaterials [Biomaterials] 2026 May; Vol. 328, pp. 123854. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery.
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  Data: <searchLink fieldCode="AU" term="%22Chen+TY%22">Chen TY</searchLink>; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CY%22">Chang CY</searchLink>; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wen+TC%22">Wen TC</searchLink>; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Peng+CL%22">Peng CL</searchLink>; Department of Isotope Application Research, National Atomic Research Institute, Taoyuan, 325207, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+YQ%22">Yeh YQ</searchLink>; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, 30076, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Research Center for Applied Science, Academia Sinica, Taipei, 115201, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+IL%22">Tsai IL</searchLink>; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: isabel10@tmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chuang+KH%22">Chuang KH</searchLink>; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 11031, Taiwan; PhD Program in Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: khchuang@tmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Wu+SH%22">Wu SH</searchLink>; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: smilehanwu@tmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%228100316%22">Biomaterials</searchLink> [Biomaterials] 2026 May; Vol. 328, pp. 123854. <i>Date of Electronic Publication: </i>2025 Nov 13.
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        Value: 10.1016/j.biomaterials.2025.123854
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              Text: 2026 May
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