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Characterization of the bone marrow architecture of multiple myeloma using spatial transcriptomics.

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Title: Characterization of the bone marrow architecture of multiple myeloma using spatial transcriptomics.
Authors: Muiños-Lopez E; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain. emuinos@unav.es., Lopez-Perez AR; Translational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Pamplona, Navarra, Spain., Sudupe L; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Vilas-Zornoza A; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain., Sarvide S; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain., Ripalda-Cemborain P; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain., Aguirre-Ruiz P; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain., Martin-Uriz PS; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain., Larrayoz M; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Alvarez-Gigli L; Departament of Pathology, Clinica Universidad de Navarra (CUN), Pamplona, Spain., Abengozar-Muela M; Departament of Pathology, Clinica Universidad de Navarra (CUN), Pamplona, Spain., Cenzano I; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Cócera M; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Ruiz J; Hospital Universitario de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., Sancho I; Hospital Universitario de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., Bantan A; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Kurowska A; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Ye J; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain., Newton PT; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Astrid Lindgren Children's hospital, Stockholm, Sweden., Paiva B; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Tamariz-Amador LE; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), IdiSNA, Pamplona, Spain., Rodriguez-Madoz JR; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Lagani V; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; SDAIA-KAUST Center of Excellence in Data Science and Artificial Intelligence, Thuwal, Saudi Arabia.; Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia.; Unit of Computational Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Tegner J; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Unit of Computational Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.; Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Science for Life Laboratory, Tomtebodavagen 23A, Solna, Sweden., Saez B; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain., Martinez-Climent JA; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Calvo IA; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain. icalvoa@unav.es.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain. icalvoa@unav.es., Gomez-Cabrero D; Translational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Pamplona, Navarra, Spain. david.gomezcabrero@kaust.edu.sa.; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. david.gomezcabrero@kaust.edu.sa., Prosper F; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain. fprosper@unav.es.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain. fprosper@unav.es.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), IdiSNA, Pamplona, Spain. fprosper@unav.es.
Source: Communications biology [Commun Biol] 2025 Nov 20; Vol. 8 (1), pp. 1620. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-025-08975-z