FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer.
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| Title: | FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer. |
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| Authors: | Ber S; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Yang M; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Sciacovelli M; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Department of Molecular and Clinical Cancer Medicine Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Samarajiwa S; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Patel K; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Nikitopoulou E; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Howitt A; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Venkitaraman AR; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Cancer Science Institute of Singapore, Singapore, 117599, Singapore.; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, 117599, Singapore.; Institute of Molecular and Cell Biology (IMCB), A(∗)STAR, Singapore, 138673, Singapore.; Department of Oncology, University of Cambridge, Cambridge, CB2 0XZ, UK.; Department of Medicine, National University of Singapore, Singapore, 119228, Singapore., Frezza C; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute of Genetics, Faculty of Mathematics and Natural Sciences, Faculty of Medicine, University of Cologne, Cologne, Germany., Esposito A; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. alessandro.esposito@brunel.ac.uk.; Centre for Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, London, UB8 3PH, UK. alessandro.esposito@brunel.ac.uk. |
| Source: | EMBO reports [EMBO Rep] 2026 Jan; Vol. 27 (1), pp. 142-162. Date of Electronic Publication: 2025 Nov 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.1038/s44319-025-00641-z |
