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Single cell long read whole genome sequencing reveals somatic transposon activity in human brain.

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Title: Single cell long read whole genome sequencing reveals somatic transposon activity in human brain.
Authors: Izydorczyk MB; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Kalef-Ezra E; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Horner DW; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Zheng X; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Holmes N; DeepSeq, School of Life Sciences, University of Nottingham, Nottingham, UK., Toffoli M; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK., Sahin Z; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Han Y; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Mehta HH; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Scholz SW; Neurodegenerative Diseases Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA., Dalgard CL; Department of Anatomy, Physiology & Genetics, Uniformed Services, University of the Health Sciences (USUHS), Bethesda, MD, USA.; The American Genome Center, USUHS, Bethesda, MD, USA., Muzny DM; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Ameur A; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Sedlazeck FJ; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. fritz.sedlazeck@bcm.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. fritz.sedlazeck@bcm.edu.; Department of Computer Science, Rice University, Houston, TX, USA. fritz.sedlazeck@bcm.edu., Proukakis C; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK. c.proukakis@ucl.ac.uk.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. c.proukakis@ucl.ac.uk.
Source: Communications biology [Commun Biol] 2025 Nov 20; Vol. 8 (1), pp. 1627. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single cell long read whole genome sequencing reveals somatic transposon activity in human brain.
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  Data: <searchLink fieldCode="AU" term="%22Izydorczyk+MB%22">Izydorczyk MB</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kalef-Ezra+E%22">Kalef-Ezra E</searchLink>; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Horner+DW%22">Horner DW</searchLink>; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Holmes+N%22">Holmes N</searchLink>; DeepSeq, School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Toffoli+M%22">Toffoli M</searchLink>; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sahin+Z%22">Sahin Z</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+HH%22">Mehta HH</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Scholz+SW%22">Scholz SW</searchLink>; Neurodegenerative Diseases Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dalgard+CL%22">Dalgard CL</searchLink>; Department of Anatomy, Physiology & Genetics, Uniformed Services, University of the Health Sciences (USUHS), Bethesda, MD, USA.; The American Genome Center, USUHS, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Muzny+DM%22">Muzny DM</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ameur+A%22">Ameur A</searchLink>; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Sedlazeck+FJ%22">Sedlazeck FJ</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. fritz.sedlazeck@bcm.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. fritz.sedlazeck@bcm.edu.; Department of Computer Science, Rice University, Houston, TX, USA. fritz.sedlazeck@bcm.edu.<br /><searchLink fieldCode="AU" term="%22Proukakis+C%22">Proukakis C</searchLink>; Department of Clinical and Movement Neurosciences, Royal Free Campus, Queen Square Institute of Neurology, University College London, London, UK. c.proukakis@ucl.ac.uk.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. c.proukakis@ucl.ac.uk.
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