HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial.
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| Title: | HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial. |
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| Authors: | Reiss EIMM; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., van der Straten K; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Graus LTM; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Grobben M; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Vlaming KE; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., van der Veen AIP; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Liesdek MH; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Corcoran M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Gao H; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Greene KM; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Yates NL; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Sawant S; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Kerster G; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Burger JA; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Schonherr S; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Cheeseman HM; Group of Mucosal Infection and Immunity, Department of Infectious Disease, Imperial College of Science, Technology and Medicine, London, UK., Evans A; Group of Mucosal Infection and Immunity, Department of Infectious Disease, Imperial College of Science, Technology and Medicine, London, UK., McFarlane LR; Group of Mucosal Infection and Immunity, Department of Infectious Disease, Imperial College of Science, Technology and Medicine, London, UK., Tran AS; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Lin RN; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Jo G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Tolazzi M; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Mundsperger P; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria., Katinger D; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria., Cupo A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Hurks R; Department of Radiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Vogt L; Department of Internal Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Dialysis and apheresis unit, Dianet, location Amsterdam UMC, Amsterdam, the Netherlands., Soeters MR; Department of Internal Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Kootstra NA; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Scarlatti G; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Tomaras GD; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Montefiori DC; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Klouwens M; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., de Jong MD; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Prins JM; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Claireaux M; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Geijtenbeek TBH; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Shattock RJ; Group of Mucosal Infection and Immunity, Department of Infectious Disease, Imperial College of Science, Technology and Medicine, London, UK., van Gils MJ; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands., Sanders RW; Department of Medical Microbiology and Infection prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands. r.w.sanders@amsterdamumc.nl.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands. r.w.sanders@amsterdamumc.nl.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA. r.w.sanders@amsterdamumc.nl., de Bree GJ; Department of Internal Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands. g.j.debree@amsterdamumc.nl. |
| Source: | Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10250. Date of Electronic Publication: 2025 Nov 21. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65101-7 |
