Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes.
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| Title: | Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes. |
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| Authors: | Uusküla-Reimand L; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Lee CA; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Oh RH; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Klein ZP; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Adler N; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Akhtar Alvi S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Langille E; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Pasini E; Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada., Cheng KCL; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Serafimova E; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Abd-Rabbo D; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Hou H; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Tsai R; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Bhat M; Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.; Division of Gastroenterology & Hepatology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Schramek D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wilson MD; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Reimand J; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Juri.Reimand@utoronto.ca. |
| Source: | Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10241. Date of Electronic Publication: 2025 Nov 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65005-6 |
