A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease.

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Title: A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease.
Authors: Shojaei Jeshvaghani Z; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States., de Vries MH; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands., van Es JH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, Utrecht 3584 CT, The Netherlands., Collen LV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States., Kotlarz D; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich 80337, Germany., Sveen M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States., Comella PH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States., Snapper SB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States., Klein C; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich 80337, Germany., Schadt EE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, Utrecht 3584 CT, The Netherlands., Mokry M; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CX, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands., Kuijk E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.; Department of Pediatrics, Lab of Cellular Disease Models, Regenerative Medicine Center Utrecht, UMC Utrecht, Utrecht 3584 CT, The Netherlands., Nieuwenhuis E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.; Princess Maximá Center for Pediatric Oncology, Utrecht 3584 CS, The Netherlands.
Source: Inflammatory bowel diseases [Inflamm Bowel Dis] 2026 Jan 01; Vol. 32 (1), pp. 9-24.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9508162 Publication Model: Print Cited Medium: Internet ISSN: 1536-4844 (Electronic) Linking ISSN: 10780998 NLM ISO Abbreviation: Inflamm Bowel Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1536-4844
DOI:10.1093/ibd/izaf296