Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context.
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| Title: | Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context. |
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| Authors: | Vourc'h M; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France; INSERM CIC 0004 Immunologie et infectiologie, Nantes Université, France. Electronic address: mickael.vourch@chu-nantes.fr., Boissier E; Laboratoire d'hématologie, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France., Lakhal K; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France., Grosjean S; Département d'Anesthésie-Réanimation, Centre Hospitalier Universitaire de Dijon, LNC UMR1231, Université Bourgogne Franche Comté, 21000 Dijon, France., Labaste F; Anesthesiology and Intensive Care Department, Centre Hospitalier Universitaire de Toulouse; Inserm U1048, I2MC-Institut des Maladies Métaboliques & Cardiovasculaires, Université Paul Sabatier, 31000 Toulouse, France., Robin E; Department of Anesthesia and Reanimation, Centre Hospitalier Universitaire de Lille, Bd du Pr Jules Leclercq, 59037 Lille, France., Bougle A; Department of Anesthesiology and Critical Care, DMU DREAM, Hôpital La Pitié-Salpêtrière, APHP 75013 Paris, France. GRC 29 - Groupe de Recherche Clinique en Anesthésie Réanimation médecine Périopératoire, ARPE, Sorbonne Université, 75013 Paris, France., Mattei M; Anesthésie et Réanimation de Chirurgie Cardiaque, Centre Hospitalier Universitaire de Nancy, 54000 Nancy, France., Morel J; Département d'anesthésie réanimation, CHU St Etienne, 25 boulevard Pasteur, 42100 Saint Etienne, France., Wurtz V; Département d'Anesthésie-Réanimation, Hôpital Charles Nicolle, Centre Hospitalier Universitaire de Rouen, 76000 Rouen, France., Mertes PM; Service d'Anesthésie Réanimation, UMR_S 1255, Nouvel Hôpital Civil - Centre Hospitalier Universitaire de Strasbourg, 83 rue Himmerich, 67000 Strasbourg, France., Zlotnik D; Department of Anesthesiology and Intensive Care, Hôpital Européen Georges Pompidou, AP-HP 75015, Paris, France. INSERM UMR-S1140 'Innovations Thérapeutiques en Hémostase', Université Paris Cité, 75004 Paris, France., Lagier D; Service d'Anesthésie Réanimation - CHU La Timone - APHM, UR 4264 - Centre Européen de Recherche en Imagerie Médicale - Aix-Marseille Université, 13000 Marseille, France., Beurton A; Department of Cardiovascular Anesthesia and Critical Care, Centre Hospitalier Universitaire de Bordeaux, INSERM, UMR 1034, Biology of Cardiovascular Diseases, Universite de Bordeaux, 33600 Pessac, France., Rineau E; Department of anesthesiology and critical care, Angers University Hospital, Angers, France; Univ Angers, MITOVASC INSERM U1083 - CNRS 6015, Team CARME, Angers, France., Fischer MO; Institut Aquitain du Coeur, Clinique Saint Augustin, ELSAN 33074 Bordeaux, France. Pôle Réanimations Anesthésie, Centre Hospitalier Universitaire de Caen, 14000 Caen, France., May MA; Anesthésie - Réanimation Chirurgicale, Centre Hospitalier Universitaire de Tours, 37000 Tours, France., Médard A; Pôle Anesthésie Réanimation, Chirurgie Cardio-vasculaire, Hôpital Gabriel Montpied, Centre Hospitalier Universitaire de Clermont Ferrand, 63003 Clermont Ferrand, France., Guimbretiere G; Department of thoracic and cardiovascular Surgery, l'Institut du Thorax, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France., Durand-Zaleski I; Service d'épidémiologie clinique, URC-Eco AP-HP, Hôtel Dieu. CRESS, Inserm, INRAE, université Paris Cité, 75004 Paris, France; Santé Publique hôpital Henri-Mondor, Université Paris Est Créteil, 94000 Créteil, France., Pere M; Plateforme de Méthodologie et Biostatistique, Direction de la Recherche et de l'Innovation, Centre Hospitalier Universitaire, Nantes, France., Rozec B; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France; Nantes Université, CNRS, INSERM, l'institut du thorax, 44093 Nantes, France., Rigal JC; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France. |
| Source: | Anaesthesia, critical care & pain medicine [Anaesth Crit Care Pain Med] 2026 May; Vol. 45 (3), pp. 101704. Date of Electronic Publication: 2025 Nov 20. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Journal Info: | Publisher: Published by Elsevier Masson SAS on behalf of the Société française d'anesthésie et de réanimation (Sfar) Country of Publication: France NLM ID: 101652401 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-5568 (Electronic) Linking ISSN: 23525568 NLM ISO Abbreviation: Anaesth Crit Care Pain Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41274376 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Vourc'h+M%22">Vourc'h M</searchLink>; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France; INSERM CIC 0004 Immunologie et infectiologie, Nantes Université, France. Electronic address: mickael.vourch@chu-nantes.fr.<br /><searchLink fieldCode="AU" term="%22Boissier+E%22">Boissier E</searchLink>; Laboratoire d'hématologie, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Lakhal+K%22">Lakhal K</searchLink>; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Grosjean+S%22">Grosjean S</searchLink>; Département d'Anesthésie-Réanimation, Centre Hospitalier Universitaire de Dijon, LNC UMR1231, Université Bourgogne Franche Comté, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Labaste+F%22">Labaste F</searchLink>; Anesthesiology and Intensive Care Department, Centre Hospitalier Universitaire de Toulouse; Inserm U1048, I2MC-Institut des Maladies Métaboliques & Cardiovasculaires, Université Paul Sabatier, 31000 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Robin+E%22">Robin E</searchLink>; Department of Anesthesia and Reanimation, Centre Hospitalier Universitaire de Lille, Bd du Pr Jules Leclercq, 59037 Lille, France.<br /><searchLink fieldCode="AU" term="%22Bougle+A%22">Bougle A</searchLink>; Department of Anesthesiology and Critical Care, DMU DREAM, Hôpital La Pitié-Salpêtrière, APHP 75013 Paris, France. GRC 29 - Groupe de Recherche Clinique en Anesthésie Réanimation médecine Périopératoire, ARPE, Sorbonne Université, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Mattei+M%22">Mattei M</searchLink>; Anesthésie et Réanimation de Chirurgie Cardiaque, Centre Hospitalier Universitaire de Nancy, 54000 Nancy, France.<br /><searchLink fieldCode="AU" term="%22Morel+J%22">Morel J</searchLink>; Département d'anesthésie réanimation, CHU St Etienne, 25 boulevard Pasteur, 42100 Saint Etienne, France.<br /><searchLink fieldCode="AU" term="%22Wurtz+V%22">Wurtz V</searchLink>; Département d'Anesthésie-Réanimation, Hôpital Charles Nicolle, Centre Hospitalier Universitaire de Rouen, 76000 Rouen, France.<br /><searchLink fieldCode="AU" term="%22Mertes+PM%22">Mertes PM</searchLink>; Service d'Anesthésie Réanimation, UMR&#95;S 1255, Nouvel Hôpital Civil - Centre Hospitalier Universitaire de Strasbourg, 83 rue Himmerich, 67000 Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Zlotnik+D%22">Zlotnik D</searchLink>; Department of Anesthesiology and Intensive Care, Hôpital Européen Georges Pompidou, AP-HP 75015, Paris, France. INSERM UMR-S1140 'Innovations Thérapeutiques en Hémostase', Université Paris Cité, 75004 Paris, France.<br /><searchLink fieldCode="AU" term="%22Lagier+D%22">Lagier D</searchLink>; Service d'Anesthésie Réanimation - CHU La Timone - APHM, UR 4264 - Centre Européen de Recherche en Imagerie Médicale - Aix-Marseille Université, 13000 Marseille, France.<br /><searchLink fieldCode="AU" term="%22Beurton+A%22">Beurton A</searchLink>; Department of Cardiovascular Anesthesia and Critical Care, Centre Hospitalier Universitaire de Bordeaux, INSERM, UMR 1034, Biology of Cardiovascular Diseases, Universite de Bordeaux, 33600 Pessac, France.<br /><searchLink fieldCode="AU" term="%22Rineau+E%22">Rineau E</searchLink>; Department of anesthesiology and critical care, Angers University Hospital, Angers, France; Univ Angers, MITOVASC INSERM U1083 - CNRS 6015, Team CARME, Angers, France.<br /><searchLink fieldCode="AU" term="%22Fischer+MO%22">Fischer MO</searchLink>; Institut Aquitain du Coeur, Clinique Saint Augustin, ELSAN 33074 Bordeaux, France. Pôle Réanimations Anesthésie, Centre Hospitalier Universitaire de Caen, 14000 Caen, France.<br /><searchLink fieldCode="AU" term="%22May+MA%22">May MA</searchLink>; Anesthésie - Réanimation Chirurgicale, Centre Hospitalier Universitaire de Tours, 37000 Tours, France.<br /><searchLink fieldCode="AU" term="%22Médard+A%22">Médard A</searchLink>; Pôle Anesthésie Réanimation, Chirurgie Cardio-vasculaire, Hôpital Gabriel Montpied, Centre Hospitalier Universitaire de Clermont Ferrand, 63003 Clermont Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Guimbretiere+G%22">Guimbretiere G</searchLink>; Department of thoracic and cardiovascular Surgery, l'Institut du Thorax, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Durand-Zaleski+I%22">Durand-Zaleski I</searchLink>; Service d'épidémiologie clinique, URC-Eco AP-HP, Hôtel Dieu. CRESS, Inserm, INRAE, université Paris Cité, 75004 Paris, France; Santé Publique hôpital Henri-Mondor, Université Paris Est Créteil, 94000 Créteil, France.<br /><searchLink fieldCode="AU" term="%22Pere+M%22">Pere M</searchLink>; Plateforme de Méthodologie et Biostatistique, Direction de la Recherche et de l'Innovation, Centre Hospitalier Universitaire, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Rozec+B%22">Rozec B</searchLink>; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France; Nantes Université, CNRS, INSERM, l'institut du thorax, 44093 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Rigal+JC%22">Rigal JC</searchLink>; Anesthésie et réanimation chirurgicale, Hôpital Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes Université, 44093 Nantes, France. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101652401%22">Anaesthesia, critical care & pain medicine</searchLink> [Anaesth Crit Care Pain Med] 2026 May; Vol. 45 (3), pp. 101704. <i>Date of Electronic Publication: </i>2025 Nov 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Published+by+Elsevier+Masson+SAS+on+behalf+of+the+Société+française+d'anesthésie+et+de+réanimation+%28Sfar%29%22">Published by Elsevier Masson SAS on behalf of the Société française d'anesthésie et de réanimation (Sfar) </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>101652401 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-5568 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223525568%22">23525568 </searchLink><i>NLM ISO Abbreviation: </i>Anaesth Crit Care Pain Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41274376 |
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