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Mouse neuronal dendritic complexity and resilience to stress-induced depression in Drosophila melanogaster are enhanced by Withania somnifera alkaloids.

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Title: Mouse neuronal dendritic complexity and resilience to stress-induced depression in Drosophila melanogaster are enhanced by Withania somnifera alkaloids.
Authors: Dutta R; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA., Holvoet H; Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-Universität Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany., Marney L; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA., Cabey K; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA., Neff C; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA., Brandes M; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA., Zweig J; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA., Martinez J; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA., Choi J; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA., McClure C; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA., Alam MN; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA., Yang L; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA., Poeck B; Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-Universität Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany., Stevens JF; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, 97331, USA., Kretzschmar D; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, USA., Gray NE; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA., Strauss R; Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-Universität Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany., Maier CS; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA., Soumyanath A; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address: soumyana@ohsu.edu.
Source: Journal of ethnopharmacology [J Ethnopharmacol] 2026 Feb 28; Vol. 357, pp. 120905. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
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  Data: Mouse neuronal dendritic complexity and resilience to stress-induced depression in Drosophila melanogaster are enhanced by Withania somnifera alkaloids.
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  Data: <searchLink fieldCode="AU" term="%22Dutta+R%22">Dutta R</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA.<br /><searchLink fieldCode="AU" term="%22Holvoet+H%22">Holvoet H</searchLink>; Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-Universität Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Marney+L%22">Marney L</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA.<br /><searchLink fieldCode="AU" term="%22Cabey+K%22">Cabey K</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Neff+C%22">Neff C</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Brandes+M%22">Brandes M</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Zweig+J%22">Zweig J</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+J%22">Martinez J</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA.<br /><searchLink fieldCode="AU" term="%22McClure+C%22">McClure C</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Alam+MN%22">Alam MN</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA.<br /><searchLink fieldCode="AU" term="%22Poeck+B%22">Poeck B</searchLink>; Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-Universität Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Stevens+JF%22">Stevens JF</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, 97331, USA.<br /><searchLink fieldCode="AU" term="%22Kretzschmar+D%22">Kretzschmar D</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Gray+NE%22">Gray NE</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Strauss+R%22">Strauss R</searchLink>; Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-Universität Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Maier+CS%22">Maier CS</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.<br /><searchLink fieldCode="AU" term="%22Soumyanath+A%22">Soumyanath A</searchLink>; BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address: soumyana@ohsu.edu.
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  Data: <searchLink fieldCode="JN" term="%227903310%22">Journal of ethnopharmacology</searchLink> [J Ethnopharmacol] 2026 Feb 28; Vol. 357, pp. 120905. <i>Date of Electronic Publication: </i>2025 Nov 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Sequoia%22">Elsevier Sequoia </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7903310 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7573 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203788741%22">03788741 </searchLink><i>NLM ISO Abbreviation: </i>J Ethnopharmacol <i>Subsets: </i>MEDLINE
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