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Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling.

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Title: Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling.
Authors: Expòsit M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA, USA., Abedi M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Krishnakumar A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Jain S; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Yu TY; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Hercus TR; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia., Mathew D; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Gray-Gaillard S; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Chen Z; Department of Chemistry, University of Chicago, Chicago, IL, USA., Grubbe WS; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Favor A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA, USA., Kan WL; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia., Schlichthaerle T; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Chen W; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Parker MW; Australian Cancer Research Foundation (ACRF) Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia., Mendoza JL; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA., Lopez AF; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia.; Department of Medicine, University of Adelaide, Adelaide, SA, Australia., Wherry EJ; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 13. Date of Electronic Publication: 2025 Oct 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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  Data: Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling.
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  Data: <searchLink fieldCode="AU" term="%22Expòsit+M%22">Expòsit M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Abedi+M%22">Abedi M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Krishnakumar+A%22">Krishnakumar A</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Jain+S%22">Jain S</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+TY%22">Yu TY</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hercus+TR%22">Hercus TR</searchLink>; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Mathew+D%22">Mathew D</searchLink>; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gray-Gaillard+S%22">Gray-Gaillard S</searchLink>; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; 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The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Schlichthaerle+T%22">Schlichthaerle T</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Parker+MW%22">Parker MW</searchLink>; Australian Cancer Research Foundation (ACRF) Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mendoza+JL%22">Mendoza JL</searchLink>; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+AF%22">Lopez AF</searchLink>; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia.; Department of Medicine, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Wherry+EJ%22">Wherry EJ</searchLink>; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
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