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Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.

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Title: Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.
Authors: Buono R; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Juarez D; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Paul M; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Skuli SJ; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Wong IB; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Tarnekar I; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Ying Z; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Le I; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Department of Chemistry, University of California Irvine, Irvine, CA, 92697, USA., Wertheim G; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Bakayoko A; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Kruidenier M; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Sebti SM; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA., Konopleva M; Albert Einstein Colege of Medicine, Montefiore Einstein Comprehensive Cancer Center, 1300 Morris Park Ave, Bronx, NY, 10461, USA., Fleischman AG; Division of Hematology-Oncology, Department of Medicine, University of California Irvine, Irvine, CA, 92697, USA., Jang C; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Department of Chemistry, University of California Irvine, Irvine, CA, 92697, USA., Carroll M; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Fruman DA; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 05. Date of Electronic Publication: 2025 Nov 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.
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  Data: <searchLink fieldCode="AU" term="%22Buono+R%22">Buono R</searchLink>; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Juarez+D%22">Juarez D</searchLink>; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Paul+M%22">Paul M</searchLink>; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Skuli+SJ%22">Skuli SJ</searchLink>; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wong+IB%22">Wong IB</searchLink>; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Tarnekar+I%22">Tarnekar I</searchLink>; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Ying+Z%22">Ying Z</searchLink>; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Le+I%22">Le I</searchLink>; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Department of Chemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Wertheim+G%22">Wertheim G</searchLink>; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Bakayoko+A%22">Bakayoko A</searchLink>; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Kruidenier+M%22">Kruidenier M</searchLink>; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Sebti+SM%22">Sebti SM</searchLink>; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA.<br /><searchLink fieldCode="AU" term="%22Konopleva+M%22">Konopleva M</searchLink>; Albert Einstein Colege of Medicine, Montefiore Einstein Comprehensive Cancer Center, 1300 Morris Park Ave, Bronx, NY, 10461, USA.<br /><searchLink fieldCode="AU" term="%22Fleischman+AG%22">Fleischman AG</searchLink>; Division of Hematology-Oncology, Department of Medicine, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Jang+C%22">Jang C</searchLink>; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Department of Chemistry, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Carroll+M%22">Carroll M</searchLink>; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Fruman+DA%22">Fruman DA</searchLink>; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
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