Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.
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| Title: | Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate. |
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| Authors: | Buono R; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Juarez D; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Paul M; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Skuli SJ; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Wong IB; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Tarnekar I; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Ying Z; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Le I; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Department of Chemistry, University of California Irvine, Irvine, CA, 92697, USA., Wertheim G; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Bakayoko A; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Kruidenier M; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Sebti SM; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA., Konopleva M; Albert Einstein Colege of Medicine, Montefiore Einstein Comprehensive Cancer Center, 1300 Morris Park Ave, Bronx, NY, 10461, USA., Fleischman AG; Division of Hematology-Oncology, Department of Medicine, University of California Irvine, Irvine, CA, 92697, USA., Jang C; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Department of Chemistry, University of California Irvine, Irvine, CA, 92697, USA., Carroll M; Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Fruman DA; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 05. Date of Electronic Publication: 2025 Nov 05. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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