Family-GWAS reveals effects of environment and mating on genetic associations.

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Title: Family-GWAS reveals effects of environment and mating on genetic associations.
Authors: Tan T; National Bureau of Economic Research, Cambridge, MA, USA., Jayashankar H; UCLA Anderson School of Management, Los Angeles, CA, USA., Guan J; UCLA Anderson School of Management, Los Angeles, CA, USA., Nehzati SM; UCLA Anderson School of Management, Los Angeles, CA, USA., Mir M; UCLA Anderson School of Management, Los Angeles, CA, USA., Bennett M; National Bureau of Economic Research, Cambridge, MA, USA., Agerbo E; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark., Ahlskog R; Department of Government, Uppsala university., Pinto de Andrade Anapaz V; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland., Åsvold BO; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, 7006, Norway., Benonisdottir S; Big Data Institute, Li Ka Shing Centre for Health Information Discovery, University of Oxford, Oxford OX3 7LF, UK., Bhatta L; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.; FIU-PH, Division of Mental Health Care, St. Olavs Hospital, Trondheim, Norway., Boomsma DI; Department of Complex Traits Genetics CNCR, Vrije Universiteit Amsterdam, De Boelelaan 1105 1081 HV Amsterdam, The Netherlands., Brumpton B; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.; Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh Bioquarter, 5-7 Little France Road, Edinburgh, EH16 4UX, United Kingdom., Chabris CF; Department of Bioethics & Decision Sciences, Geisinger Health System, 100 North Academy Avenue, Danville, PA 17822 USA., Cheesman R; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway., Chen Z; Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK., de Geus E; Department of Biological Psychology, Vrije Universiteit Amsterdam, De Boelelaan 1105 1081 HV Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center, De Boelelaan 1117 1081 HV Amsterdam, the Netherlands., Ehli EA; Avera Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD 57105, USA., Elnahas AG; Institute of Genomics, University of Tartu, Tartu, Estonia., Ganna A; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland.; Analytic & Translational Genetics Unit, Massachusetts General Hospital, Boston, USA., Giannelis A; Department of Psychology, University of Minnesota Twin Cities, 75 East River Road, Minneapolis, MN 55455, USA., Hakaste L; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland.; Folkhalsan Research Center, Helsinki, FIN-00140 FInland., Hansen AF; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway., Havdahl A; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom., Hottenga JJ; Avera Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD 57105, USA.; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, De Boelelaan 1105 1081 HV Amsterdam, The Netherlands., Houmark MA; Department of Economics and Business Economics and TrygFonden's Centre for Child Research, Aarhus University, Fuglesangs Allé 4, 8210 Aarhus V, Denmark., Hveem K; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway., Kaprio J; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland., Langhammer A; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway., Latvala A; Institute of Criminology and Legal Policy, University of Helsinki., Lee JJ; Department of Psychology, University of Minnesota Twin Cities, 75 East River Road, Minneapolis, MN 55455, USA., Lehtovirta M; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland., Li L; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Xueyuan Road, Haidian District, 100191, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, 100191, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, 100191, Beijing, China., Lin K; Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK., Linnér RK; Department of Economics, Leiden Law School, Leiden University, Steenschuur 25, 2311 ES Leiden, the Netherlands.; Autism and Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Lewisburg, PA 17837, USA.; School of Business and Economics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, the Netherlands., Lombardi S; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland.; VATT Institute for Economic Research, Finland., Martin NG; Mental Health & Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., McGue M; Department of Psychology, University of Minnesota Twin Cities, 75 East River Road, Minneapolis, MN 55455, USA., Medland SE; Mental Health & Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Metspalu A; Institute of Genomics, University of Tartu, Tartu, Estonia.; Estonian Biobank Research Team: Andres Metspalu, Mari Nelis, Lili Milani, Reedik Mägi, Georgi Hudjashov & Tõnu Esko., Mitchell BL; Mental Health & Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Ni G; Institute for Molecular Bioscience, University of Queensland, Australia., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Oetjens MT; Autism and Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Lewisburg, PA 17837, USA., Oskarsson S; Department of Government, Uppsala university., Palviainen T; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland., Prasad RB; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland.; Lund University Diabetes Centre, Malmo, Sweden., Reigo A; Institute of Genomics, University of Tartu, Tartu, Estonia., Reis K; Institute of Genomics, University of Tartu, Tartu, Estonia., Sidorenko J; Institute for Molecular Bioscience, University of Queensland, Australia., Silventoinen K; Helsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Tuomi T; Institute for Molecular Medicine Finland FIMM, HILife, University of Helsinki, Helsinki, FIN-00140 Finland.; Folkhalsan Research Center, Helsinki, FIN-00140 FInland.; Lund University Diabetes Centre, Malmo, Sweden.; Endocrinology, Abdominal Centre, Helsinki University Hospital, Po Box 340, FIN-0029, Helsinki, Finland., Vilhjálmsson BJ; National Centre for Register-based Research, Aarhus University.; Bioinformatics Research Centre, Dept. of Molecular Biology and Genetics, Aarhus University.; Novo Nordisk Foundation Center for Genomics Mechanisms of Disease, the Broad Institute of MIT and Harvard., Walters RG; Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK., Willoughby EA; Department of Psychology, University of Minnesota Twin Cities, 75 East River Road, Minneapolis, MN 55455, USA., Winsvold BS; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway., Ystrom E; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway., Flint J; UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA., Yengo L; Institute for Molecular Bioscience, University of Queensland, Australia., Visscher PM; Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.; Institute for Molecular Bioscience, University of Queensland, Australia., Kong A; Leverhulme Centre for Demographic Science, Nuffield Department of Population Health, University of Oxford and Nuffield College, UK., Tucker-Drob EM; Department of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Stop A8000, Austin, TX 78712, USA., Border R; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 885 Tiverton Dr., Los Angeles, CA 90095.; Department of Computer Science, University of California, Los Angeles, Los Angeles, CA 90095., Cesarini D; National Bureau of Economic Research, Cambridge, MA, USA.; Department of Economics, New York University, New York, NY.; Research Institute of Industrial Economics (IFN), Stockholm, Sweden., Turley P; Department of Economics, University of Southern California, Los Angeles, CA, USA.; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA., Okbay A; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Benjamin DJ; National Bureau of Economic Research, Cambridge, MA, USA.; UCLA Anderson School of Management, Los Angeles, CA, USA.; Human Genetics Department, UCLA David Geffen School of Medicine, Los Angeles, CA, US., Young AS; UCLA Anderson School of Management, Los Angeles, CA, USA.; Human Genetics Department, UCLA David Geffen School of Medicine, Los Angeles, CA, US.
Corporate Authors: China Kadoorie Biobank Collaborative Group, Estonian Biobank Research Team, Finngen, LifeLines Cohort Study
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Oct 14. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2024.10.01.24314703