Effects of Non-Cardiac/Non-neurologic Surgery and Anaesthesia on the CSF Proteome, and Modulation by the APOE Mimetic Peptide CN-105.

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Title: Effects of Non-Cardiac/Non-neurologic Surgery and Anaesthesia on the CSF Proteome, and Modulation by the APOE Mimetic Peptide CN-105.
Authors: Zou H; Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Lutz MW; Department of Neurology, Duke University School of Medicine, Durham, NC, USA.; Duke-UNC Alzheimers Disease Research Center, Duke University Medical Center, Durham, NC, USA., Foster MW; Proteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Wright MC; Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA., Violette MJ; Proteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC, USA., Luo S; Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA.; Duke-UNC Alzheimers Disease Research Center, Duke University Medical Center, Durham, NC, USA., Laskowitz D; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Devinney MJ; Duke-UNC Alzheimers Disease Research Center, Duke University Medical Center, Durham, NC, USA.; Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.; These authors contributed equally to this manuscript and are co-senior authors., Berger M; Duke-UNC Alzheimers Disease Research Center, Duke University Medical Center, Durham, NC, USA.; Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.; These authors contributed equally to this manuscript and are co-senior authors.; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine & Stanford Health, Stanford CA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Oct 07. Date of Electronic Publication: 2025 Oct 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.10.06.25337433