Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.

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Title: Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.
Authors: Schweickart A; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Buck Institute for Research on Aging, Novato, CA, USA., Batra R; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Huynh K; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, Victoria, Australia., Blach C; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA., Kueider-Paisley A; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA., Reddy JS; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Klein G; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, Victoria, Australia., Zhang B; Department of Genetics and Genomic Sciences; Mount Sinai Center for Transformative Disease Modeling; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., De Jager PL; Center for Translational and Computational Neuroimmunology; Department of Neurology; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Heath L; Sage Bionetworks, Seattle, WA, USA., Beck J; Sage Bionetworks, Seattle, WA, USA., Scanlan J; Sage Bionetworks, Seattle, WA, USA., Seyfried NT; Department of Neurology, Emory University School of Medicine; Department of Biochemistry, Emory University, Atlanta, GA, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Kaddurah-Daouk R; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA., Arnold M; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA.; Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Krumsiek J; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Corporate Authors: AMP-AD Diverse Cohorts Working Group, Alzheimer’s Disease Metabolomics Consortium
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Nov 07. Date of Electronic Publication: 2025 Nov 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.11.04.25339489