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Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.

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Title: Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.
Authors: Schweickart A; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Buck Institute for Research on Aging, Novato, CA, USA., Batra R; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Huynh K; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, Victoria, Australia., Blach C; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA., Kueider-Paisley A; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA., Reddy JS; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Klein G; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, Victoria, Australia., Zhang B; Department of Genetics and Genomic Sciences; Mount Sinai Center for Transformative Disease Modeling; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., De Jager PL; Center for Translational and Computational Neuroimmunology; Department of Neurology; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Heath L; Sage Bionetworks, Seattle, WA, USA., Beck J; Sage Bionetworks, Seattle, WA, USA., Scanlan J; Sage Bionetworks, Seattle, WA, USA., Seyfried NT; Department of Neurology, Emory University School of Medicine; Department of Biochemistry, Emory University, Atlanta, GA, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Kaddurah-Daouk R; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA., Arnold M; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA.; Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Krumsiek J; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Corporate Authors: AMP-AD Diverse Cohorts Working Group, Alzheimer’s Disease Metabolomics Consortium
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Nov 07. Date of Electronic Publication: 2025 Nov 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.
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  Data: <searchLink fieldCode="AU" term="%22Schweickart+A%22">Schweickart A</searchLink>; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Batra+R%22">Batra R</searchLink>; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huynh+K%22">Huynh K</searchLink>; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Blach+C%22">Blach C</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kueider-Paisley+A%22">Kueider-Paisley A</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+JS%22">Reddy JS</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Klein+G%22">Klein G</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Meikle+PJ%22">Meikle PJ</searchLink>; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Department of Genetics and Genomic Sciences; Mount Sinai Center for Transformative Disease Modeling; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Center for Translational and Computational Neuroimmunology; Department of Neurology; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Heath+L%22">Heath L</searchLink>; Sage Bionetworks, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Beck+J%22">Beck J</searchLink>; Sage Bionetworks, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Scanlan+J%22">Scanlan J</searchLink>; Sage Bionetworks, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Seyfried+NT%22">Seyfried NT</searchLink>; Department of Neurology, Emory University School of Medicine; Department of Biochemistry, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Dickson+DW%22">Dickson DW</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ertekin-Taner+N%22">Ertekin-Taner N</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kaddurah-Daouk+R%22">Kaddurah-Daouk R</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+M%22">Arnold M</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, NC, USA.; Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Krumsiek+J%22">Krumsiek J</searchLink>; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
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  Data: <searchLink fieldCode="CA" term="%22AMP-AD+Diverse+Cohorts+Working+Group%2C+Alzheimer%27s+Disease+Metabolomics+Consortium%22">AMP-AD Diverse Cohorts Working Group, Alzheimer’s Disease Metabolomics Consortium</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2025 Nov 07. <i>Date of Electronic Publication: </i>2025 Nov 07.
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PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41282904
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        Value: 10.1101/2025.11.04.25339489
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