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Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia.

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Bibliographic Details
Title: Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia.
Authors: Guggilla V; Institute for Artificial Intelligence in Medicine, Northwestern University Feinberg School of Medicine, 625 N Michigan Ave, 15th Floor, Chicago, Illinois 60611, USA., Pickens CO; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Donnelly HK; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Pawlowski A; Northwestern Medicine Enterprise Data Warehouse, Northwestern University Feinberg School of Medicine, 420 E Superior St, Chicago, Illinois 60611, USA., Korth E; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Martinez F; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Clepp RK; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Budinger GS; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA., Misharin AV; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA., Nadig NR; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Singer BD; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA., Gao CA; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Walunas TL; Institute for Artificial Intelligence in Medicine, Northwestern University Feinberg School of Medicine, 625 N Michigan Ave, 15th Floor, Chicago, Illinois 60611, USA.; Division of General Internal Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, 750 N Lake Shore Dr, 10th Floor, Chicago, Illinois 60611, USA., Wunderink RG; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA.
Corporate Authors: NU SCRIPT Study Investigators
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Nov 06. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.11.05.25339543