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Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis.

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Title: Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis.
Authors: Selvarani R; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA., Lee S; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA., Saminathan M; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India., Boovalingam P; Regional Research and Educational Centre, TANUVAS, Pudukkottai, Tamilnadu, India., Kurup K; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA., Pham K; Genes & Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Wolf RF; Oklahoma City Veterans Affairs Health Care System, Oklahoma City, OK, USA., Freeman WM; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.; Genes & Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.; Oklahoma City Veterans Affairs Health Care System, Oklahoma City, OK, USA., Unnikrishnan A; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.; Harold Hamm Diabetes Center, OU Health, Oklahoma City, OK, USA.; Oklahoma Center for Geroscience and Healthy Brain Aging, Oklahoma City, OK, USA., Richardson A; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA. Arlan-richardson@ouhsc.edu.; Oklahoma City Veterans Affairs Health Care System, Oklahoma City, OK, USA. Arlan-richardson@ouhsc.edu.; Oklahoma Center for Geroscience and Healthy Brain Aging, Oklahoma City, OK, USA. Arlan-richardson@ouhsc.edu.
Source: GeroScience [Geroscience] 2026 Apr; Vol. 48 (2), pp. 1917-1935. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Selvarani+R%22">Selvarani R</searchLink>; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Saminathan+M%22">Saminathan M</searchLink>; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Boovalingam+P%22">Boovalingam P</searchLink>; Regional Research and Educational Centre, TANUVAS, Pudukkottai, Tamilnadu, India.<br /><searchLink fieldCode="AU" term="%22Kurup+K%22">Kurup K</searchLink>; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Pham+K%22">Pham K</searchLink>; Genes & Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Wolf+RF%22">Wolf RF</searchLink>; Oklahoma City Veterans Affairs Health Care System, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+WM%22">Freeman WM</searchLink>; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.; Genes & Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.; Oklahoma City Veterans Affairs Health Care System, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Unnikrishnan+A%22">Unnikrishnan A</searchLink>; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.; Harold Hamm Diabetes Center, OU Health, Oklahoma City, OK, USA.; Oklahoma Center for Geroscience and Healthy Brain Aging, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+A%22">Richardson A</searchLink>; Biochemistry & Physiology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA. Arlan-richardson@ouhsc.edu.; Oklahoma City Veterans Affairs Health Care System, Oklahoma City, OK, USA. Arlan-richardson@ouhsc.edu.; Oklahoma Center for Geroscience and Healthy Brain Aging, Oklahoma City, OK, USA. Arlan-richardson@ouhsc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Apr; Vol. 48 (2), pp. 1917-1935. <i>Date of Electronic Publication: </i>2025 Nov 24.
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  Data: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41283975
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        Value: 10.1007/s11357-025-01994-y
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      – Code: eng
        Text: English
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        StartPage: 1917
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      – TitleFull: Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis.
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            – D: 01
              M: 04
              Text: 2026 Apr
              Type: published
              Y: 2026
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