Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial.

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Title: Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial.
Authors: Zhang ZN; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China., Hao XY; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China., Cai C; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China., Sun L; Department of Anesthesiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China., Zhang ZY; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Wang M; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Wu YS; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Wang Y; Department of Psychosomatic Medicine, Honghui Hospital, Xi'an Jiaotong University, China., Cao JB; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Liu YH; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Lou JS; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Fu Q; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Jiang SL; Department of Cardiovascular Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Han RQ; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Mi WD; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100036, China. Electronic address: wwdd1962@163.com., Tong L; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address: tongli301@aliyun.com.
Source: Pharmacological research [Pharmacol Res] 2025 Dec; Vol. 222, pp. 108047. Date of Electronic Publication: 2025 Nov 22.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-1186
DOI:10.1016/j.phrs.2025.108047