Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial.

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Title: Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial.
Authors: Zhang ZN; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China., Hao XY; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China., Cai C; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China., Sun L; Department of Anesthesiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China., Zhang ZY; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Wang M; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Wu YS; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Wang Y; Department of Psychosomatic Medicine, Honghui Hospital, Xi'an Jiaotong University, China., Cao JB; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Liu YH; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Lou JS; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Fu Q; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Jiang SL; Department of Cardiovascular Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Han RQ; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Mi WD; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100036, China. Electronic address: wwdd1962@163.com., Tong L; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address: tongli301@aliyun.com.
Source: Pharmacological research [Pharmacol Res] 2025 Dec; Vol. 222, pp. 108047. Date of Electronic Publication: 2025 Nov 22.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+ZN%22">Zhang ZN</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hao+XY%22">Hao XY</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+C%22">Cai C</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; Medical School of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; Department of Anesthesiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZY%22">Zhang ZY</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+YS%22">Wu YS</searchLink>; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Psychosomatic Medicine, Honghui Hospital, Xi'an Jiaotong University, China.<br /><searchLink fieldCode="AU" term="%22Cao+JB%22">Cao JB</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+YH%22">Liu YH</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lou+JS%22">Lou JS</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Fu+Q%22">Fu Q</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+SL%22">Jiang SL</searchLink>; Department of Cardiovascular Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Han+RQ%22">Han RQ</searchLink>; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Mi+WD%22">Mi WD</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100036, China. Electronic address: wwdd1962@163.com.<br /><searchLink fieldCode="AU" term="%22Tong+L%22">Tong L</searchLink>; Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address: tongli301@aliyun.com.
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  Data: <searchLink fieldCode="JN" term="%228907422%22">Pharmacological research</searchLink> [Pharmacol Res] 2025 Dec; Vol. 222, pp. 108047. <i>Date of Electronic Publication: </i>2025 Nov 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8907422 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-1186 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210436618%22">10436618 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacol Res <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.phrs.2025.108047
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        Text: English
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        StartPage: 108047
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              M: 12
              Text: 2025 Dec
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              Y: 2025
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