High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures.
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| Title: | High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures. |
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| Authors: | Cabug AF; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Crawford JC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN, USA., McQuilten HA; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Foo IJH; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Allen LF; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Gebregzabher D; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Mettelman RC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Novak T; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, USA., Chou J; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Rowntree LC; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Hagen RR; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Thomson AJ; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Martin GE; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Gilbertson B; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Souter MN; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., James F; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Goodall E; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Rizzetto S; School of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Flerlage T; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA., Jia X; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Van de Velde LA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Chang SY; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Luciani F; School of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Thwaites RS; National Heart and Lung Institute, Imperial College London, London, UK., Trubiano JA; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC, Australia.; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Kotsimbos TC; Department of Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, Australia.; Department of Medicine, Central Clinical School, The Alfred Hospital, Monash University, Melbourne, VIC, Australia., Cheng AC; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Monash Infectious Diseases, Monash Health and School of Clinical Sciences, Monash University, Clayton, VIC, Australia., Randolph AG; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA., Xu J; Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China., Wang Z; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China., Nguyen THO; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Chua BY; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Kedzierski L; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Kedzierska K; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. kkedz@unimelb.edu.au.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA. kkedz@unimelb.edu.au. |
| Source: | Nature communications [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 10344. Date of Electronic Publication: 2025 Nov 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65262-5 |
