High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures.
Saved in:
| Title: | High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures. |
|---|---|
| Authors: | Cabug AF; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Crawford JC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN, USA., McQuilten HA; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Foo IJH; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Allen LF; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Gebregzabher D; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Mettelman RC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Novak T; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, USA., Chou J; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Rowntree LC; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Hagen RR; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Thomson AJ; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Martin GE; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Gilbertson B; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Souter MN; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., James F; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Goodall E; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Rizzetto S; School of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Flerlage T; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA., Jia X; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Van de Velde LA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Chang SY; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Luciani F; School of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Thwaites RS; National Heart and Lung Institute, Imperial College London, London, UK., Trubiano JA; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC, Australia.; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Kotsimbos TC; Department of Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, Australia.; Department of Medicine, Central Clinical School, The Alfred Hospital, Monash University, Melbourne, VIC, Australia., Cheng AC; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Monash Infectious Diseases, Monash Health and School of Clinical Sciences, Monash University, Clayton, VIC, Australia., Randolph AG; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA., Xu J; Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China., Wang Z; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China., Nguyen THO; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Chua BY; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Kedzierski L; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Kedzierska K; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. kkedz@unimelb.edu.au.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA. kkedz@unimelb.edu.au. |
| Source: | Nature communications [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 10344. Date of Electronic Publication: 2025 Nov 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41285788 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Cabug+AF%22">Cabug AF</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Crawford+JC%22">Crawford JC</searchLink>; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22McQuilten+HA%22">McQuilten HA</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Foo+IJH%22">Foo IJH</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Allen+LF%22">Allen LF</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gebregzabher+D%22">Gebregzabher D</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mettelman+RC%22">Mettelman RC</searchLink>; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Novak+T%22">Novak T</searchLink>; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chou+J%22">Chou J</searchLink>; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rowntree+LC%22">Rowntree LC</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hagen+RR%22">Hagen RR</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Thomson+AJ%22">Thomson AJ</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Martin+GE%22">Martin GE</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gilbertson+B%22">Gilbertson B</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Souter+MN%22">Souter MN</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22James+F%22">James F</searchLink>; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Goodall+E%22">Goodall E</searchLink>; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Rizzetto+S%22">Rizzetto S</searchLink>; School of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Flerlage+T%22">Flerlage T</searchLink>; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jia+X%22">Jia X</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Van+de+Velde+LA%22">Van de Velde LA</searchLink>; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chang+SY%22">Chang SY</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Luciani+F%22">Luciani F</searchLink>; School of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Thwaites+RS%22">Thwaites RS</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Trubiano+JA%22">Trubiano JA</searchLink>; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC, Australia.; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kotsimbos+TC%22">Kotsimbos TC</searchLink>; Department of Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, Australia.; Department of Medicine, Central Clinical School, The Alfred Hospital, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cheng+AC%22">Cheng AC</searchLink>; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Monash Infectious Diseases, Monash Health and School of Clinical Sciences, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Randolph+AG%22">Randolph AG</searchLink>; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+PG%22">Thomas PG</searchLink>; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Nguyen+THO%22">Nguyen THO</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chua+BY%22">Chua BY</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kedzierski+L%22">Kedzierski L</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kedzierska+K%22">Kedzierska K</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. kkedz@unimelb.edu.au.; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA. kkedz@unimelb.edu.au. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 10344. <i>Date of Electronic Publication: </i>2025 Nov 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41285788 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-65262-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 10344 Titles: – TitleFull: High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cabug AF – PersonEntity: Name: NameFull: Crawford JC – PersonEntity: Name: NameFull: McQuilten HA – PersonEntity: Name: NameFull: Foo IJH – PersonEntity: Name: NameFull: Allen LF – PersonEntity: Name: NameFull: Gebregzabher D – PersonEntity: Name: NameFull: Mettelman RC – PersonEntity: Name: NameFull: Novak T – PersonEntity: Name: NameFull: Chou J – PersonEntity: Name: NameFull: Rowntree LC – PersonEntity: Name: NameFull: Hagen RR – PersonEntity: Name: NameFull: Thomson AJ – PersonEntity: Name: NameFull: Martin GE – PersonEntity: Name: NameFull: Gilbertson B – PersonEntity: Name: NameFull: Souter MN – PersonEntity: Name: NameFull: James F – PersonEntity: Name: NameFull: Goodall E – PersonEntity: Name: NameFull: Rizzetto S – PersonEntity: Name: NameFull: Flerlage T – PersonEntity: Name: NameFull: Jia X – PersonEntity: Name: NameFull: Van de Velde LA – PersonEntity: Name: NameFull: Chang SY – PersonEntity: Name: NameFull: Luciani F – PersonEntity: Name: NameFull: Thwaites RS – PersonEntity: Name: NameFull: Trubiano JA – PersonEntity: Name: NameFull: Kotsimbos TC – PersonEntity: Name: NameFull: Cheng AC – PersonEntity: Name: NameFull: Randolph AG – PersonEntity: Name: NameFull: Thomas PG – PersonEntity: Name: NameFull: Xu J – PersonEntity: Name: NameFull: Wang Z – PersonEntity: Name: NameFull: Nguyen THO – PersonEntity: Name: NameFull: Chua BY – PersonEntity: Name: NameFull: Kedzierski L – PersonEntity: Name: NameFull: Kedzierska K IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 11 Text: 2025 Nov 24 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
| ResultId | 1 |
