BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.

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Title: BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.
Authors: Xing YY; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China., Huang Y; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Cheng T; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China. chengtao2ldo@zju.edu.cn., Tian YM; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Dong Y; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China., Jin ZX; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Pu HR; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Luo T; Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China., Liu X; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Shen HN; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Mo J; Department of Immunology, School of Basic Medicine, Guizhou Medical University, 561113, Guiyang, Guizhou, China., Ma J; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Ji JF; Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China., Xu PF; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China. pengfei_xu@zju.edu.cn.; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China. pengfei_xu@zju.edu.cn.
Source: The EMBO journal [EMBO J] 2026 Jan; Vol. 45 (1), pp. 210-242. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00643-6