BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.

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Title: BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.
Authors: Xing YY; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China., Huang Y; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Cheng T; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China. chengtao2ldo@zju.edu.cn., Tian YM; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Dong Y; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China., Jin ZX; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Pu HR; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Luo T; Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China., Liu X; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Shen HN; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Mo J; Department of Immunology, School of Basic Medicine, Guizhou Medical University, 561113, Guiyang, Guizhou, China., Ma J; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China., Ji JF; Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China., Xu PF; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China. pengfei_xu@zju.edu.cn.; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China. pengfei_xu@zju.edu.cn.
Source: The EMBO journal [EMBO J] 2026 Jan; Vol. 45 (1), pp. 210-242. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.
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  Data: <searchLink fieldCode="AU" term="%22Xing+YY%22">Xing YY</searchLink>; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Cheng+T%22">Cheng T</searchLink>; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China. chengtao2ldo@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tian+YM%22">Tian YM</searchLink>; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Jin+ZX%22">Jin ZX</searchLink>; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Pu+HR%22">Pu HR</searchLink>; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Luo+T%22">Luo T</searchLink>; Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Shen+HN%22">Shen HN</searchLink>; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Mo+J%22">Mo J</searchLink>; Department of Immunology, School of Basic Medicine, Guizhou Medical University, 561113, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Ji+JF%22">Ji JF</searchLink>; Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Xu+PF%22">Xu PF</searchLink>; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China. pengfei_xu@zju.edu.cn.; Center for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, 322000, Yiwu, Zhejiang, China. pengfei_xu@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Jan; Vol. 45 (1), pp. 210-242. <i>Date of Electronic Publication: </i>2025 Nov 24.
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        Value: 10.1038/s44318-025-00643-6
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