Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.

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Title: Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.
Authors: Minetti A; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Omrani O; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Brenner C; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.; Institute of Pathology, Section of Pediatric Pathology, University Hospital Bonn, Bonn, Germany., Cansiz F; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany., Imada S; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA., Rösler J; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany., Khawaled S; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA., Allies G; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany., Meckelmann SW; Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany., Gebert N; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Heinze I; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Rahnis N; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Lu J; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Spengler K; Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany., Rasa M; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.; Institute of Biotechnology, Department of Technical Immunology, Technical University Berlin, Berlin, Germany., Cirri E; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Heller R; Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany., Yilmaz Ö; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology, Beth Israel Deaconess Medical Center and Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tasdogan A; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.; Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany., Neri F; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany. francesco.neri@unito.it.; Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy. francesco.neri@unito.it.; Molecular Biotechnology Center, University of Turin, Turin, Italy. francesco.neri@unito.it., Ori A; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany. alessandro.ori@leibniz-fli.de.; Genentech Inc., San Francisco, CA, USA. alessandro.ori@leibniz-fli.de.
Source: Nature cell biology [Nat Cell Biol] 2025 Dec; Vol. 27 (12), pp. 2063-2077. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4679
DOI:10.1038/s41556-025-01804-9