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Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.

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Title: Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.
Authors: Minetti A; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Omrani O; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Brenner C; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.; Institute of Pathology, Section of Pediatric Pathology, University Hospital Bonn, Bonn, Germany., Cansiz F; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany., Imada S; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA., Rösler J; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany., Khawaled S; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA., Allies G; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany., Meckelmann SW; Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany., Gebert N; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Heinze I; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Rahnis N; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Lu J; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Spengler K; Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany., Rasa M; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.; Institute of Biotechnology, Department of Technical Immunology, Technical University Berlin, Berlin, Germany., Cirri E; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany., Heller R; Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany., Yilmaz Ö; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology, Beth Israel Deaconess Medical Center and Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tasdogan A; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.; Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany., Neri F; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany. francesco.neri@unito.it.; Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy. francesco.neri@unito.it.; Molecular Biotechnology Center, University of Turin, Turin, Italy. francesco.neri@unito.it., Ori A; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany. alessandro.ori@leibniz-fli.de.; Genentech Inc., San Francisco, CA, USA. alessandro.ori@leibniz-fli.de.
Source: Nature cell biology [Nat Cell Biol] 2025 Dec; Vol. 27 (12), pp. 2063-2077. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.
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  Data: <searchLink fieldCode="AU" term="%22Minetti+A%22">Minetti A</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Omrani+O%22">Omrani O</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Brenner+C%22">Brenner C</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.; Institute of Pathology, Section of Pediatric Pathology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Cansiz+F%22">Cansiz F</searchLink>; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Imada+S%22">Imada S</searchLink>; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rösler+J%22">Rösler J</searchLink>; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Khawaled+S%22">Khawaled S</searchLink>; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Allies+G%22">Allies G</searchLink>; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Meckelmann+SW%22">Meckelmann SW</searchLink>; Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Gebert+N%22">Gebert N</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Heinze+I%22">Heinze I</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Rahnis+N%22">Rahnis N</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Spengler+K%22">Spengler K</searchLink>; Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Rasa+M%22">Rasa M</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.; Institute of Biotechnology, Department of Technical Immunology, Technical University Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Cirri+E%22">Cirri E</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Heller+R%22">Heller R</searchLink>; Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Yilmaz+Ö%22">Yilmaz Ö</searchLink>; Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology, Beth Israel Deaconess Medical Center and Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tasdogan+A%22">Tasdogan A</searchLink>; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.; Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Neri+F%22">Neri F</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany. francesco.neri@unito.it.; Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy. francesco.neri@unito.it.; Molecular Biotechnology Center, University of Turin, Turin, Italy. francesco.neri@unito.it.<br /><searchLink fieldCode="AU" term="%22Ori+A%22">Ori A</searchLink>; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany. alessandro.ori@leibniz-fli.de.; Genentech Inc., San Francisco, CA, USA. alessandro.ori@leibniz-fli.de.
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  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2025 Dec; Vol. 27 (12), pp. 2063-2077. <i>Date of Electronic Publication: </i>2025 Nov 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Macmillan+Magazines+Ltd%22">Macmillan Magazines Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100890575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4679 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214657392%22">14657392 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cell Biol <i>Subsets: </i>MEDLINE
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