Detection of Titin-Associated Electrocardiography Features in Dilated Cardiomyopathy Using Conventional and Deep Neural Network Analysis.

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Title: Detection of Titin-Associated Electrocardiography Features in Dilated Cardiomyopathy Using Conventional and Deep Neural Network Analysis.
Authors: Heymans ABM; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands., van de Leur RR; Department of Cardiology, University Medical Center, Utrecht, the Netherlands., Wang P; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands., González-López E; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain., Venner MFGHM; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands., Beelen NJ; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands., Muller SA; Department of Cardiology, University Medical Center, Utrecht, the Netherlands., Mora-Ayestarán N; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain., Ramos N; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain., Faassen IME; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands., Stroeks SLVM; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands., Soria M; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain., van der Crabben SN; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands., Ter Bekke RMA; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands., van Es R; Department of Cardiology, University Medical Center, Utrecht, the Netherlands., Vernooy K; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands., Te Riele ASJM; Department of Cardiology, University Medical Center, Utrecht, the Netherlands; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands., García-Pavía P; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases, Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands., Heymans SRB; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands; Department of Cardiovascular Sciences, Center for Vascular and Molecular Biology, KU Leuven, Leuven, Belgium; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands. Electronic address: astrid.heymans@maastrichtuniversity.nl., Verdonschot JAJ; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands. Electronic address: job.verdonschot@mumc.nl.
Source: JACC. Clinical electrophysiology [JACC Clin Electrophysiol] 2026 Feb; Vol. 12 (2), pp. 363-374. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101656995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-5018 (Electronic) Linking ISSN: 2405500X NLM ISO Abbreviation: JACC Clin Electrophysiol Subsets: MEDLINE
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  Data: Detection of Titin-Associated Electrocardiography Features in Dilated Cardiomyopathy Using Conventional and Deep Neural Network Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Heymans+ABM%22">Heymans ABM</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Leur+RR%22">van de Leur RR</searchLink>; Department of Cardiology, University Medical Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22González-López+E%22">González-López E</searchLink>; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Venner+MFGHM%22">Venner MFGHM</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Beelen+NJ%22">Beelen NJ</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Muller+SA%22">Muller SA</searchLink>; Department of Cardiology, University Medical Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mora-Ayestarán+N%22">Mora-Ayestarán N</searchLink>; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos+N%22">Ramos N</searchLink>; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Faassen+IME%22">Faassen IME</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Stroeks+SLVM%22">Stroeks SLVM</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Soria+M%22">Soria M</searchLink>; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22van+der+Crabben+SN%22">van der Crabben SN</searchLink>; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ter+Bekke+RMA%22">Ter Bekke RMA</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Es+R%22">van Es R</searchLink>; Department of Cardiology, University Medical Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vernooy+K%22">Vernooy K</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Te+Riele+ASJM%22">Te Riele ASJM</searchLink>; Department of Cardiology, University Medical Center, Utrecht, the Netherlands; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22García-Pavía+P%22">García-Pavía P</searchLink>; Department of Cardiology, Hospital Universitario Puerta de Hierro, Majadahonda Madrid, Spain; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases, Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Heymans+SRB%22">Heymans SRB</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands; Department of Cardiovascular Sciences, Center for Vascular and Molecular Biology, KU Leuven, Leuven, Belgium; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands. Electronic address: astrid.heymans@maastrichtuniversity.nl.<br /><searchLink fieldCode="AU" term="%22Verdonschot+JAJ%22">Verdonschot JAJ</searchLink>; Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht and Maastricht University Medical Center, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands; European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart, Amsterdam, the Netherlands. Electronic address: job.verdonschot@mumc.nl.
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