The O-GlcNAcylation of β-actin Ser199 controls nuclear speckle localization and is dysregulated in diabetes.

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Title: The O-GlcNAcylation of β-actin Ser199 controls nuclear speckle localization and is dysregulated in diabetes.
Authors: Akimoto Y; Department of Microscopic Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan. yakimoto@ks.kyorin-u.ac.jp., Miura Y; Research Team for the Mechanism of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, Tokyo, 173-0015, Japan., Kudo A; Department of Microscopic Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan., Fukutomi T; Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan., Arai T; Department of Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, Tokyo, 173-0015, Japan., Chiba Y; Department of Clinical Laboratory, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, Tokyo, 173-0015, Japan., Kaname S; Department of Internal Medicine, Kichijoji Asahi Hospital, Musashino, Tokyo, 180-0004, Japan.; Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan., Yan K; Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan., Hart GW; Center for Complex Carbohydrates, University of Georgia, Athens, GA, 30602, USA.
Source: Histochemistry and cell biology [Histochem Cell Biol] 2025 Nov 25; Vol. 163 (1), pp. 106. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-119X
DOI:10.1007/s00418-025-02429-7