Protocol for a phase IV, Experimental Human Pneumococcal Challenge (EHPC) model to investigate Streptococcus pneumoniae serotype 3 (SPN3) colonisation following PCV15, a double-blind randomised controlled trial in healthy participants aged 18-50 years in the UK (RATIONALE-15).

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Title: Protocol for a phase IV, Experimental Human Pneumococcal Challenge (EHPC) model to investigate Streptococcus pneumoniae serotype 3 (SPN3) colonisation following PCV15, a double-blind randomised controlled trial in healthy participants aged 18-50 years in the UK (RATIONALE-15).
Authors: Macedo BR; Department of Paediatrics, University of Oxford, Oxford, UK., Solórzano C; Department of Paediatrics, University of Oxford, Oxford, UK., Hyder-Wright A; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Lustosa Martinelli J; Department of Paediatrics, University of Oxford, Oxford, UK., Robinson H; Department of Paediatrics, University of Oxford, Oxford, UK., Brito-Mutunayagam S; Department of Paediatrics, University of Oxford, Oxford, UK., Urban BC; Department of Paediatrics, University of Oxford, Oxford, UK., Codreanu T; Department of Paediatrics, University of Oxford, Oxford, UK., Elterish F; Department of Paediatrics, University of Oxford, Oxford, UK., Mitsi E; Department of Paediatrics, University of Oxford, Oxford, UK., Howard A; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., El Safadi D; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Tanha K; Department of Paediatrics, University of Oxford, Oxford, UK., Liu X; Department of Paediatrics, University of Oxford, Oxford, UK., Mazur O; Department of Paediatrics, University of Oxford, Oxford, UK., Ramasamy MN; Department of Paediatrics, University of Oxford, Oxford, UK., Collins A; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Ferreira DM; Department of Paediatrics, University of Oxford, Oxford, UK daniela.ferreira@paediatrics.ox.ac.uk., Drysdale SB; Department of Paediatrics, University of Oxford, Oxford, UK.
Source: BMJ open [BMJ Open] 2025 Nov 24; Vol. 15 (11), pp. e106028. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2044-6055
DOI:10.1136/bmjopen-2025-106028