Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury.
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| Title: | Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury. |
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| Authors: | Fischer JC; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany. julius.fischer@tum.de.; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France. julius.fischer@tum.de.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France. julius.fischer@tum.de., Göttert S; Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Giller M; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Heinrich P; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Fan K; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Khalid O; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Walther CN; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Department of Nephrology, Technical University Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Drießlein M; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Nefzger SM; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Eisenkolb G; Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Department of Gynecology and Obstetrics, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Timnik VR; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Jarosch S; Technical University of Munich (TUM), TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany., Klostermeier L; Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Engleitner T; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; Technical University of Munich (TUM), TUM School of Medicine and Health, Institute of Molecular Oncology and Functional Genomics, Munich, Germany., Strieder N; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Gebhard C; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Diederich S; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Schmid NA; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Lansink Rotgerink L; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Joachim L; Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Ghimire S; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Vonbrunn E; Department of Nephropathology, Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Büttner-Herold M; Department of Nephropathology, Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Remke M; Technical University of Munich (TUM), TUM School of Medicine and Health, Comparative Experimental Pathology, Munich, Germany.; Technical University of Munich (TUM), TUM School of Medicine and Health, Institute of Pathology, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, A partnership between DKFZ and TUM University Hospital, Munich, Germany., Steiger K; Technical University of Munich (TUM), TUM School of Medicine and Health, Comparative Experimental Pathology, Munich, Germany.; Technical University of Munich (TUM), TUM School of Medicine and Health, Institute of Pathology, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, A partnership between DKFZ and TUM University Hospital, Munich, Germany., Öllinger R; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; Technical University of Munich (TUM), TUM School of Medicine and Health, Institute of Molecular Oncology and Functional Genomics, Munich, Germany., Rad R; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; Technical University of Munich (TUM), TUM School of Medicine and Health, Institute of Molecular Oncology and Functional Genomics, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, A partnership between DKFZ and TUM University Hospital, Munich, Germany.; Department of Medicine II, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany., Wolff D; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Feuerer M; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Hoffmann P; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Edinger M; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Rehli M; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Tschurtschenthaler M; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, A partnership between DKFZ and TUM University Hospital, Munich, Germany.; Technical University of Munich, TUM School of Medicine and Health, TUM University Hospital, Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Munich, Germany., Kepp O; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Kroemer G; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.; Institut du Cancer Paris CARPEM, Hôpital Européen Georges Pompidou, France-HP, Paris, France., Thiele Orberg E; Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Combs SE; Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, A partnership between DKFZ and TUM University Hospital, Munich, Germany., Herr W; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Bassermann F; Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, A partnership between DKFZ and TUM University Hospital, Munich, Germany.; Bavarian Cancer Research Centre (BZKF), Munich, Germany., Busch DH; Technical University of Munich (TUM), TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany., Holler E; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany., Heidegger S; Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.; Technical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany., Poeck H; University Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany. hendrik.poeck@ukr.de.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. hendrik.poeck@ukr.de.; Bavarian Cancer Research Centre (BZKF), Regensburg, Germany. hendrik.poeck@ukr.de. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Nov 26; Vol. 10 (1), pp. 384. Date of Electronic Publication: 2025 Nov 26. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-025-02476-5 |
