Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum.
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| Title: | Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum. |
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| Authors: | Webster R; QIMR Berghofer, Brisbane, QLD 4006, Australia., Oyong DA; Burnet Institute, Melbourne, VIC 3004, Australia., Llewellyn S; QIMR Berghofer, Brisbane, QLD 4006, Australia.; George Institute for Global Health, NSW 2031, Australia., Abd-Rahman AN; QIMR Berghofer, Brisbane, QLD 4006, Australia., Potter AJ; QIMR Berghofer, Brisbane, QLD 4006, Australia., Mukhiya R; Burnet Institute, Melbourne, VIC 3004, Australia.; Griffith University, Brisbane, QLD 4101, Australia., Sahai N; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Leelasena I; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Ujvary E; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Mathison S; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Andrew DW; QIMR Berghofer, Brisbane, QLD 4006, Australia., Bukali L; QIMR Berghofer, Brisbane, QLD 4006, Australia., de Labastida Rivera F; QIMR Berghofer, Brisbane, QLD 4006, Australia., Engel J; QIMR Berghofer, Brisbane, QLD 4006, Australia., Soon MSF; Burnet Institute, Melbourne, VIC 3004, Australia., Frame T; QIMR Berghofer, Brisbane, QLD 4006, Australia., Hamelink J; Burnet Institute, Melbourne, VIC 3004, Australia.; University of Queensland, Brisbane, QLD 4000, Australia., Nalubega M; Burnet Institute, Melbourne, VIC 3004, Australia.; University of Queensland, Brisbane, QLD 4000, Australia., Dooley NL; Burnet Institute, Melbourne, VIC 3004, Australia., Loughland JR; Burnet Institute, Melbourne, VIC 3004, Australia., Nguyen T; Stanford University, Stanford, CA 94305, USA., Rosenberg-Hasson Y; Stanford University, Stanford, CA 94305, USA., Maysel-Auslender S; Stanford University, Stanford, CA 94305, USA., Sigal N; Stanford University, Stanford, CA 94305, USA., Foygel K; Stanford University, Stanford, CA 94305, USA., Gower J; QIMR Berghofer, Brisbane, QLD 4006, Australia., Peters J; QIMR Berghofer, Brisbane, QLD 4006, Australia., Woo R; QIMR Berghofer, Brisbane, QLD 4006, Australia., Amante F; QIMR Berghofer, Brisbane, QLD 4006, Australia., Wells TNC; Medicines for Malaria Venture, Geneva 1215, Switzerland., Chalon S; Medicines for Malaria Venture, Geneva 1215, Switzerland., Moehrle JJ; Medicines for Malaria Venture, Geneva 1215, Switzerland.; University of Basel, Basel 4056, Switzerland.; Swiss Tropical and Public Health Institute, Allschwil 4123, Switzerland., McCarthy JS; QIMR Berghofer, Brisbane, QLD 4006, Australia.; Department of Infectious Diseases, University of Melbourne Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Birrell GW; Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4053, Australia., Edstein MD; Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4053, Australia., Leipold M; Stanford University, Stanford, CA 94305, USA., Obermoser G; Stanford University, Stanford, CA 94305, USA., Maecker H; Stanford University, Stanford, CA 94305, USA., Engwerda CR; QIMR Berghofer, Brisbane, QLD 4006, Australia., Barber BE; QIMR Berghofer, Brisbane, QLD 4006, Australia.; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia.; Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.; Menzies School of Health Research, Darwin, NT 0810, Australia., Boyle MJ; Burnet Institute, Melbourne, VIC 3004, Australia.; Griffith University, Brisbane, QLD 4101, Australia.; University of Queensland, Brisbane, QLD 4000, Australia. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Nov 26; Vol. 17 (826), pp. eaea2531. Date of Electronic Publication: 2025 Nov 26. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aea2531 |
