View in EDS HTML Full Text PDF Full Text

Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum.

Saved in:
Bibliographic Details
Title: Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum.
Authors: Webster R; QIMR Berghofer, Brisbane, QLD 4006, Australia., Oyong DA; Burnet Institute, Melbourne, VIC 3004, Australia., Llewellyn S; QIMR Berghofer, Brisbane, QLD 4006, Australia.; George Institute for Global Health, NSW 2031, Australia., Abd-Rahman AN; QIMR Berghofer, Brisbane, QLD 4006, Australia., Potter AJ; QIMR Berghofer, Brisbane, QLD 4006, Australia., Mukhiya R; Burnet Institute, Melbourne, VIC 3004, Australia.; Griffith University, Brisbane, QLD 4101, Australia., Sahai N; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Leelasena I; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Ujvary E; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Mathison S; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia., Andrew DW; QIMR Berghofer, Brisbane, QLD 4006, Australia., Bukali L; QIMR Berghofer, Brisbane, QLD 4006, Australia., de Labastida Rivera F; QIMR Berghofer, Brisbane, QLD 4006, Australia., Engel J; QIMR Berghofer, Brisbane, QLD 4006, Australia., Soon MSF; Burnet Institute, Melbourne, VIC 3004, Australia., Frame T; QIMR Berghofer, Brisbane, QLD 4006, Australia., Hamelink J; Burnet Institute, Melbourne, VIC 3004, Australia.; University of Queensland, Brisbane, QLD 4000, Australia., Nalubega M; Burnet Institute, Melbourne, VIC 3004, Australia.; University of Queensland, Brisbane, QLD 4000, Australia., Dooley NL; Burnet Institute, Melbourne, VIC 3004, Australia., Loughland JR; Burnet Institute, Melbourne, VIC 3004, Australia., Nguyen T; Stanford University, Stanford, CA 94305, USA., Rosenberg-Hasson Y; Stanford University, Stanford, CA 94305, USA., Maysel-Auslender S; Stanford University, Stanford, CA 94305, USA., Sigal N; Stanford University, Stanford, CA 94305, USA., Foygel K; Stanford University, Stanford, CA 94305, USA., Gower J; QIMR Berghofer, Brisbane, QLD 4006, Australia., Peters J; QIMR Berghofer, Brisbane, QLD 4006, Australia., Woo R; QIMR Berghofer, Brisbane, QLD 4006, Australia., Amante F; QIMR Berghofer, Brisbane, QLD 4006, Australia., Wells TNC; Medicines for Malaria Venture, Geneva 1215, Switzerland., Chalon S; Medicines for Malaria Venture, Geneva 1215, Switzerland., Moehrle JJ; Medicines for Malaria Venture, Geneva 1215, Switzerland.; University of Basel, Basel 4056, Switzerland.; Swiss Tropical and Public Health Institute, Allschwil 4123, Switzerland., McCarthy JS; QIMR Berghofer, Brisbane, QLD 4006, Australia.; Department of Infectious Diseases, University of Melbourne Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Birrell GW; Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4053, Australia., Edstein MD; Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4053, Australia., Leipold M; Stanford University, Stanford, CA 94305, USA., Obermoser G; Stanford University, Stanford, CA 94305, USA., Maecker H; Stanford University, Stanford, CA 94305, USA., Engwerda CR; QIMR Berghofer, Brisbane, QLD 4006, Australia., Barber BE; QIMR Berghofer, Brisbane, QLD 4006, Australia.; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia.; Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.; Menzies School of Health Research, Darwin, NT 0810, Australia., Boyle MJ; Burnet Institute, Melbourne, VIC 3004, Australia.; Griffith University, Brisbane, QLD 4101, Australia.; University of Queensland, Brisbane, QLD 4000, Australia.
Source: Science translational medicine [Sci Transl Med] 2025 Nov 26; Vol. 17 (826), pp. eaea2531. Date of Electronic Publication: 2025 Nov 26.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41296825
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Webster+R%22">Webster R</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Oyong+DA%22">Oyong DA</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Llewellyn+S%22">Llewellyn S</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.; George Institute for Global Health, NSW 2031, Australia.<br /><searchLink fieldCode="AU" term="%22Abd-Rahman+AN%22">Abd-Rahman AN</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Potter+AJ%22">Potter AJ</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Mukhiya+R%22">Mukhiya R</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.; Griffith University, Brisbane, QLD 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Sahai+N%22">Sahai N</searchLink>; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Leelasena+I%22">Leelasena I</searchLink>; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Ujvary+E%22">Ujvary E</searchLink>; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Mathison+S%22">Mathison S</searchLink>; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Andrew+DW%22">Andrew DW</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Bukali+L%22">Bukali L</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22de+Labastida+Rivera+F%22">de Labastida Rivera F</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Engel+J%22">Engel J</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Soon+MSF%22">Soon MSF</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Frame+T%22">Frame T</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Hamelink+J%22">Hamelink J</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.; University of Queensland, Brisbane, QLD 4000, Australia.<br /><searchLink fieldCode="AU" term="%22Nalubega+M%22">Nalubega M</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.; University of Queensland, Brisbane, QLD 4000, Australia.<br /><searchLink fieldCode="AU" term="%22Dooley+NL%22">Dooley NL</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Loughland+JR%22">Loughland JR</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Rosenberg-Hasson+Y%22">Rosenberg-Hasson Y</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Maysel-Auslender+S%22">Maysel-Auslender S</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Sigal+N%22">Sigal N</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Foygel+K%22">Foygel K</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Gower+J%22">Gower J</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Peters+J%22">Peters J</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Woo+R%22">Woo R</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Amante+F%22">Amante F</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Wells+TNC%22">Wells TNC</searchLink>; Medicines for Malaria Venture, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chalon+S%22">Chalon S</searchLink>; Medicines for Malaria Venture, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moehrle+JJ%22">Moehrle JJ</searchLink>; Medicines for Malaria Venture, Geneva 1215, Switzerland.; University of Basel, Basel 4056, Switzerland.; Swiss Tropical and Public Health Institute, Allschwil 4123, Switzerland.<br /><searchLink fieldCode="AU" term="%22McCarthy+JS%22">McCarthy JS</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.; Department of Infectious Diseases, University of Melbourne Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Birrell+GW%22">Birrell GW</searchLink>; Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4053, Australia.<br /><searchLink fieldCode="AU" term="%22Edstein+MD%22">Edstein MD</searchLink>; Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4053, Australia.<br /><searchLink fieldCode="AU" term="%22Leipold+M%22">Leipold M</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Obermoser+G%22">Obermoser G</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Maecker+H%22">Maecker H</searchLink>; Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Engwerda+CR%22">Engwerda CR</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Barber+BE%22">Barber BE</searchLink>; QIMR Berghofer, Brisbane, QLD 4006, Australia.; University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia.; Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.; Menzies School of Health Research, Darwin, NT 0810, Australia.<br /><searchLink fieldCode="AU" term="%22Boyle+MJ%22">Boyle MJ</searchLink>; Burnet Institute, Melbourne, VIC 3004, Australia.; Griffith University, Brisbane, QLD 4101, Australia.; University of Queensland, Brisbane, QLD 4000, Australia.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Nov 26; Vol. 17 (826), pp. eaea2531. <i>Date of Electronic Publication: </i>2025 Nov 26.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Randomized Controlled Trial
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41296825
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/scitranslmed.aea2531
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: eaea2531
    Titles:
      – TitleFull: Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Webster R
      – PersonEntity:
          Name:
            NameFull: Oyong DA
      – PersonEntity:
          Name:
            NameFull: Llewellyn S
      – PersonEntity:
          Name:
            NameFull: Abd-Rahman AN
      – PersonEntity:
          Name:
            NameFull: Potter AJ
      – PersonEntity:
          Name:
            NameFull: Mukhiya R
      – PersonEntity:
          Name:
            NameFull: Sahai N
      – PersonEntity:
          Name:
            NameFull: Leelasena I
      – PersonEntity:
          Name:
            NameFull: Ujvary E
      – PersonEntity:
          Name:
            NameFull: Mathison S
      – PersonEntity:
          Name:
            NameFull: Andrew DW
      – PersonEntity:
          Name:
            NameFull: Bukali L
      – PersonEntity:
          Name:
            NameFull: de Labastida Rivera F
      – PersonEntity:
          Name:
            NameFull: Engel J
      – PersonEntity:
          Name:
            NameFull: Soon MSF
      – PersonEntity:
          Name:
            NameFull: Frame T
      – PersonEntity:
          Name:
            NameFull: Hamelink J
      – PersonEntity:
          Name:
            NameFull: Nalubega M
      – PersonEntity:
          Name:
            NameFull: Dooley NL
      – PersonEntity:
          Name:
            NameFull: Loughland JR
      – PersonEntity:
          Name:
            NameFull: Nguyen T
      – PersonEntity:
          Name:
            NameFull: Rosenberg-Hasson Y
      – PersonEntity:
          Name:
            NameFull: Maysel-Auslender S
      – PersonEntity:
          Name:
            NameFull: Sigal N
      – PersonEntity:
          Name:
            NameFull: Foygel K
      – PersonEntity:
          Name:
            NameFull: Gower J
      – PersonEntity:
          Name:
            NameFull: Peters J
      – PersonEntity:
          Name:
            NameFull: Woo R
      – PersonEntity:
          Name:
            NameFull: Amante F
      – PersonEntity:
          Name:
            NameFull: Wells TNC
      – PersonEntity:
          Name:
            NameFull: Chalon S
      – PersonEntity:
          Name:
            NameFull: Moehrle JJ
      – PersonEntity:
          Name:
            NameFull: McCarthy JS
      – PersonEntity:
          Name:
            NameFull: Birrell GW
      – PersonEntity:
          Name:
            NameFull: Edstein MD
      – PersonEntity:
          Name:
            NameFull: Leipold M
      – PersonEntity:
          Name:
            NameFull: Obermoser G
      – PersonEntity:
          Name:
            NameFull: Maecker H
      – PersonEntity:
          Name:
            NameFull: Engwerda CR
      – PersonEntity:
          Name:
            NameFull: Barber BE
      – PersonEntity:
          Name:
            NameFull: Boyle MJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 11
              Text: 2025 Nov 26
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 826
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1