Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice.
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| Title: | Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice. |
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| Authors: | Höckendorf U; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany., Dutta S; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Kloos A; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Runtsch M; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.; Cycuria Therapeutics, Graz, Austria., Zötsch C; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.; Cycuria Therapeutics, Graz, Austria., Vosberg S; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Wang Y; Proteomics and Cancer Cell Signaling, DKFZ and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany and Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Heidelberg, Germany., Kienreich S; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Flasch B; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Malovan G; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Jäger V; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Stanzer S; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Prein S; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Odinius TO; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany.; Department of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland., Wagner CV; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany., Buschhorn L; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, University Hospital and German Cancer Research Center (DKFZ), Heidelberg, Germany., Dill V; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany., Perfler B; Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.; Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria., Haferlach T; Munich Leukemia Laboratory (MLL), Munich, Germany., Döhner K; Ulm University Hospital, Department of Internal Medicine III, Ulm, Germany., Götze KS; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany., Ruland J; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany.; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany., Bassermann F; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.; TranslaTUM, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany., Wahida A; Institute of Metabolism and Cell Death, Helmholtz Centre Munich, Neuherberg, Germany., Heikenwälder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Branca C; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany., Schmöllerl J; Research Institute of Molecular Pathology, Vienna BioCenter (VBC), Vienna, Austria., Zuber J; Research Institute of Molecular Pathology, Vienna BioCenter (VBC), Vienna, Austria.; Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria., Burk AC; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany., Zeiser R; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany., Sill H; Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Jayavelu AK; Proteomics and Cancer Cell Signaling, DKFZ and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany and Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Heidelberg, Germany., Zebisch A; Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.; Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria., Heuser M; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.; Department of Internal Medicine IV, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany., Dengler MA; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Jost PJ; Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, München, Germany.; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.; BioTechMed, Graz and Austrian Comprehensive Cancer Network (ACCN), Graz, Austria. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Nov 26; Vol. 17 (826), pp. eadu3313. Date of Electronic Publication: 2025 Nov 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adu3313 |
