Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.

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Title: Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.
Authors: Chen SC; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Chou CC; Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan., Chen WM; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Sheu SY; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Huang LW; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Huang CH; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Chang SC; Department of Microbiology, Soochow University, Taipei 11102, Taiwan., Kuo CH; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan. Electronic address: kuoch@nkust.edu.tw., Hsu CH; Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan; Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei 10617, Taiwan; Center for Computational and Systems Biology, National Taiwan University, Taipei 10617, Taiwan. Electronic address: andyhsu@ntu.edu.tw.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Jan; Vol. 335 (Pt 1), pp. 149194. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2025.149194