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Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.

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Title: Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.
Authors: Chen SC; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Chou CC; Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan., Chen WM; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Sheu SY; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Huang LW; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Huang CH; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Chang SC; Department of Microbiology, Soochow University, Taipei 11102, Taiwan., Kuo CH; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan. Electronic address: kuoch@nkust.edu.tw., Hsu CH; Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan; Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei 10617, Taiwan; Center for Computational and Systems Biology, National Taiwan University, Taipei 10617, Taiwan. Electronic address: andyhsu@ntu.edu.tw.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Jan; Vol. 335 (Pt 1), pp. 149194. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.
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  Data: <searchLink fieldCode="AU" term="%22Chen+SC%22">Chen SC</searchLink>; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+CC%22">Chou CC</searchLink>; Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WM%22">Chen WM</searchLink>; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sheu+SY%22">Sheu SY</searchLink>; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+LW%22">Huang LW</searchLink>; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CH%22">Huang CH</searchLink>; Department of Marine Biotechnology, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+SC%22">Chang SC</searchLink>; Department of Microbiology, Soochow University, Taipei 11102, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+CH%22">Kuo CH</searchLink>; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan. Electronic address: kuoch@nkust.edu.tw.<br /><searchLink fieldCode="AU" term="%22Hsu+CH%22">Hsu CH</searchLink>; Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan; Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei 10617, Taiwan; Center for Computational and Systems Biology, National Taiwan University, Taipei 10617, Taiwan. Electronic address: andyhsu@ntu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2026 Jan; Vol. 335 (Pt 1), pp. 149194. <i>Date of Electronic Publication: </i>2025 Nov 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7909578 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201418130%22">01418130 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Macromol <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.ijbiomac.2025.149194
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      – Code: eng
        Text: English
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        StartPage: 149194
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      – TitleFull: Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.
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              Text: 2026 Jan
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