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Early mucosal IFN-α, IP-10, and IL-1RA and synchronized mucosal and systemic immune responses mediate COVID-19 disease progression.

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Title: Early mucosal IFN-α, IP-10, and IL-1RA and synchronized mucosal and systemic immune responses mediate COVID-19 disease progression.
Authors: Agrawal M; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Flores-Torres AS; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Franks JS; Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee, USA., Lang SY; Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Fabrizio TP; Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee, USA., McNair KE; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA., Boywid LV; Children's Foundation Research Institute, Memphis, Tennessee, USA., Blair AJ; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Hundman CN; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA., Hysmith ND; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.; Children's Foundation Research Institute, Memphis, Tennessee, USA., Whitt MA; Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Keating R; Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia., Thomas PG; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, Tennessee, USA., Webby RJ; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, Tennessee, USA., Green AM; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.; Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA., Smallwood HS; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.; Children's Foundation Research Institute, Memphis, Tennessee, USA.
Source: MBio [mBio] 2026 Jan 14; Vol. 17 (1), pp. e0149125. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early mucosal IFN-α, IP-10, and IL-1RA and synchronized mucosal and systemic immune responses mediate COVID-19 disease progression.
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  Data: <searchLink fieldCode="AU" term="%22Agrawal+M%22">Agrawal M</searchLink>; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Flores-Torres+AS%22">Flores-Torres AS</searchLink>; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Franks+JS%22">Franks JS</searchLink>; Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Lang+SY%22">Lang SY</searchLink>; Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Fabrizio+TP%22">Fabrizio TP</searchLink>; Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22McNair+KE%22">McNair KE</searchLink>; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Boywid+LV%22">Boywid LV</searchLink>; Children's Foundation Research Institute, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Blair+AJ%22">Blair AJ</searchLink>; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Hundman+CN%22">Hundman CN</searchLink>; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Hysmith+ND%22">Hysmith ND</searchLink>; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.; Children's Foundation Research Institute, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Whitt+MA%22">Whitt MA</searchLink>; Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Keating+R%22">Keating R</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Thomas+PG%22">Thomas PG</searchLink>; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Webby+RJ%22">Webby RJ</searchLink>; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Green+AM%22">Green AM</searchLink>; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.; Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Smallwood+HS%22">Smallwood HS</searchLink>; Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.; Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.; Children's Foundation Research Institute, Memphis, Tennessee, USA.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2026 Jan 14; Vol. 17 (1), pp. e0149125. <i>Date of Electronic Publication: </i>2025 Nov 28.
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              Text: 2026 Jan 14
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