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Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study.

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Title: Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study.
Authors: Stubbs BJ; Buck Institute for Research on Aging, Novato, CA, USA. Electronic address: bstubbs@buckinstitute.org., Stephens EB; Buck Institute for Research on Aging, Novato, CA, USA., Mansfield T; San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA., Senadheera C; Buck Institute for Research on Aging, Novato, CA, USA., Diaz SR; Buck Institute for Research on Aging, Novato, CA, USA., Peralta S; Buck Institute for Research on Aging, Novato, CA, USA., Alexander L; Buck Institute for Research on Aging, Novato, CA, USA., Silverman-Martin W; Buck Institute for Research on Aging, Novato, CA, USA., Kurtzig J; Buck Institute for Research on Aging, Novato, CA, USA., Fernando BA; Phenome Health, Seattle, WA, USA., Garcia TY; Buck Institute for Research on Aging, Novato, CA, USA., Yukawa M; Veteran's Affairs Medical Center, San Francisco, CA, USA; Division of Geriatrics, University of California, San Francisco, CA, USA., Morris J; Veteran's Affairs Medical Center, San Francisco, CA, USA; Division of Geriatrics, University of California, San Francisco, CA, USA., Yurkovich JT; Buck Institute for Research on Aging, Novato, CA, USA; Phenome Health, Seattle, WA, USA., Newman AB; University of Pittsburgh, PA, USA., Johnson JB; Independent Researcher, Greenbrae, CA, USA., Cawthon PM; San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA., Newman JC; Buck Institute for Research on Aging, Novato, CA, USA; Division of Geriatrics, University of California, San Francisco, CA, USA. Electronic address: jnewman@buckinstitute.org.
Source: The Journal of frailty & aging [J Frailty Aging] 2025 Dec; Vol. 14 (6), pp. 100106. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101604797 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2260-1341 (Print) Linking ISSN: 22601341 NLM ISO Abbreviation: J Frailty Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study.
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  Data: <searchLink fieldCode="AU" term="%22Stubbs+BJ%22">Stubbs BJ</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA. Electronic address: bstubbs@buckinstitute.org.<br /><searchLink fieldCode="AU" term="%22Stephens+EB%22">Stephens EB</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mansfield+T%22">Mansfield T</searchLink>; San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Senadheera+C%22">Senadheera C</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Diaz+SR%22">Diaz SR</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Peralta+S%22">Peralta S</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+L%22">Alexander L</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Silverman-Martin+W%22">Silverman-Martin W</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kurtzig+J%22">Kurtzig J</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fernando+BA%22">Fernando BA</searchLink>; Phenome Health, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+TY%22">Garcia TY</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yukawa+M%22">Yukawa M</searchLink>; Veteran's Affairs Medical Center, San Francisco, CA, USA; Division of Geriatrics, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Morris+J%22">Morris J</searchLink>; Veteran's Affairs Medical Center, San Francisco, CA, USA; Division of Geriatrics, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yurkovich+JT%22">Yurkovich JT</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA; Phenome Health, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Newman+AB%22">Newman AB</searchLink>; University of Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+JB%22">Johnson JB</searchLink>; Independent Researcher, Greenbrae, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cawthon+PM%22">Cawthon PM</searchLink>; San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Newman+JC%22">Newman JC</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA; Division of Geriatrics, University of California, San Francisco, CA, USA. Electronic address: jnewman@buckinstitute.org.
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  Data: <searchLink fieldCode="JN" term="%22101604797%22">The Journal of frailty & aging</searchLink> [J Frailty Aging] 2025 Dec; Vol. 14 (6), pp. 100106. <i>Date of Electronic Publication: </i>2025 Nov 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101604797 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2260-1341 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222601341%22">22601341 </searchLink><i>NLM ISO Abbreviation: </i>J Frailty Aging <i>Subsets: </i>MEDLINE
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              Text: 2025 Dec
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