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A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infection.

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Title: A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infection.
Authors: Cheng X; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China. Electronic address: Xiaoming.cheng@whu.edu.cn., Xia Y; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China., Li C; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China., Zhang M; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Inuzuka T; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Chakka S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Chen Q; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China., Teng Y; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China., Mao J; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China., Li X; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China., Dong W; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, China., Mouzannar K; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Chih-Chien Cheng K; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Liang TJ; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA. Electronic address: jake.liang@nih.gov.
Source: Journal of hepatology [J Hepatol] 2026 May; Vol. 84 (5), pp. 874-886. Date of Electronic Publication: 2025 Nov 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China. Electronic address: Xiaoming.cheng@whu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Inuzuka+T%22">Inuzuka T</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Chakka+S%22">Chakka S</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Teng+Y%22">Teng Y</searchLink>; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Mao+J%22">Mao J</searchLink>; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Pathology, TaiKang Medical School, Zhongnan Hospital, Wuhan University, Wuhan, China; State Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Dong+W%22">Dong W</searchLink>; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Mouzannar+K%22">Mouzannar K</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Chih-Chien+Cheng+K%22">Chih-Chien Cheng K</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Liang+TJ%22">Liang TJ</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA. Electronic address: jake.liang@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2026 May; Vol. 84 (5), pp. 874-886. <i>Date of Electronic Publication: </i>2025 Nov 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jhep.2025.11.017
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        Text: English
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