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Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis.

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Title: Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis.
Authors: Langtry A; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Rabadan R; Department of Systems Biology, Columbia University, New York, NY, USA., Alonso L; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Filip I; Department of Systems Biology, Columbia University, New York, NY, USA., Sabroso-Lasa S; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Moreno-Oya A; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Lawlor R; ARC-Net Center for Applied Research on Cancer, Department of Diagnostics and Public Health, Verona, Italy.; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Carrato A; CIBERONC, Madrid, Spain.; Department of Oncology, Ramón y Cajal University Hospital, Madrid, Spain.; Instituto Ramón y Cajal de investigación sanitaria (IRYCIS), Madrid, and CIBERONC, Madrid, Spain.; Alcala University, Madrid, Spain., Alvarez-Gallego R; HM CIOCC Madrid (Centro Integral Oncológico Clara Campal). Hospital Universitario HM Sanchinarro. Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain.; Facultad HM de Ciencias de la Salud de la Universidad Camilo José Cela, Madrid, Spain., Iglesias M; CIBERONC, Madrid, Spain.; Department of Pathology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Molero X; Department of Gastroenterology, Hospital Vall Hebron, Barcelona, Spain.; Hospitals Universitaris Arnau de Vilanova i Santa Maria, IRBLleida, UdL, Lleida, Spain.; CIBEREHD, Madrid, Spain., Löhr MJ; Gastrocentrum, Karolinska Institutet and University Hospital, Stockholm, Sweden., Michalski CW; Department of Surgery, Technical University of Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, Medical Faculty Heidelberg, University Heidelberg, Heidelberg, Germany., Perea J; Department of Surgery, Hospital 12 de Octubre, Madrid, Spain.; Institute of Biomedical Research of Salamanca, Salamanca, Spain., O'Rorke M; Centre for Public Health, Belfast, Queen's University Belfast, Belfast, UK.; College of Public Health, The University of Iowa, Iowa City, IA, US., Barberà VM; Molecular Genetics Laboratory, General University Hospital of Elche, Elche, Spain., Tardón A; Department of Medicine, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; CIBERESP, Madrid, Spain., Farré A; Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Muñoz-Bellvís L; Department of Surgery, Hospital Universitario de Salamanca - IBSAL, Universidad de Salamanca, Salamanca; and CIBERONC, Madrid, Spain., Crnogorac-Jurcevic T; Barts Cancer Institute, Centre for Cancer Biomarkers and Biotherapeutics, Queen Mary University of London, London, UK., Domínguez-Muñoz E; Department of Gastroenterology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain., Gress TM; Department of Gastroenterology, University Hospital of Giessen and Marburg, Marburg, Germany., Greenhalf W; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Sharp L; National Cancer Registry Ireland and HRB Clinical Research Facility, University College Cork, Cork, Ireland.; Newcastle University, Institute of Health & Society, Newcastle, UK., Balsells J; Department of Surgery, Hospital Vall Hebron, Barcelona, Spain., Costello E; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Kleeff J; Department of Surgery, Technical University of Munich, Munich, Germany.; Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Wittenber-Halle (Saale), Halle (Saale), Germany., Kong B; Department of Surgery, Technical University of Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, Medical Faculty Heidelberg, University Heidelberg, Heidelberg, Germany., Mora J; Department of Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., O'Driscoll D; National Cancer Registry Ireland and HRB Clinical Research Facility, University College Cork, Cork, Ireland., Scarpa A; ARC-Net Center for Applied Research on Cancer, Department of Diagnostics and Public Health, Verona, Italy.; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Ye W; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stokholm, Sweden., Real FX; CIBERONC, Madrid, Spain.; Epithelial Carcinogenesis Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Pompeu Fabra University, Barcelona, Spain., López de Maturana E; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. melopezdm@cnio.es.; CIBERONC, Madrid, Spain. melopezdm@cnio.es., Malats N; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. nmalats@cnio.es.; CIBERONC, Madrid, Spain. nmalats@cnio.es.
Corporate Authors: PanGenEU Consortium Investigators
Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10769. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis.
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  Data: <searchLink fieldCode="AU" term="%22Langtry+A%22">Langtry A</searchLink>; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rabadan+R%22">Rabadan R</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alonso+L%22">Alonso L</searchLink>; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Filip+I%22">Filip I</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sabroso-Lasa+S%22">Sabroso-Lasa S</searchLink>; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno-Oya+A%22">Moreno-Oya A</searchLink>; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lawlor+R%22">Lawlor R</searchLink>; ARC-Net Center for Applied Research on Cancer, Department of Diagnostics and Public Health, Verona, Italy.; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Carrato+A%22">Carrato A</searchLink>; CIBERONC, Madrid, Spain.; Department of Oncology, Ramón y Cajal University Hospital, Madrid, Spain.; Instituto Ramón y Cajal de investigación sanitaria (IRYCIS), Madrid, and CIBERONC, Madrid, Spain.; Alcala University, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alvarez-Gallego+R%22">Alvarez-Gallego R</searchLink>; HM CIOCC Madrid (Centro Integral Oncológico Clara Campal). 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Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain.; Facultad HM de Ciencias de la Salud de la Universidad Camilo José Cela, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias+M%22">Iglesias M</searchLink>; CIBERONC, Madrid, Spain.; Department of Pathology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Molero+X%22">Molero X</searchLink>; Department of Gastroenterology, Hospital Vall Hebron, Barcelona, Spain.; Hospitals Universitaris Arnau de Vilanova i Santa Maria, IRBLleida, UdL, Lleida, Spain.; CIBEREHD, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Löhr+MJ%22">Löhr MJ</searchLink>; Gastrocentrum, Karolinska Institutet and University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Michalski+CW%22">Michalski CW</searchLink>; Department of Surgery, Technical University of Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, Medical Faculty Heidelberg, University Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Perea+J%22">Perea J</searchLink>; 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Department of Surgery, Hospital Universitario de Salamanca - IBSAL, Universidad de Salamanca, Salamanca; and CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Crnogorac-Jurcevic+T%22">Crnogorac-Jurcevic T</searchLink>; Barts Cancer Institute, Centre for Cancer Biomarkers and Biotherapeutics, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Domínguez-Muñoz+E%22">Domínguez-Muñoz E</searchLink>; Department of Gastroenterology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Gress+TM%22">Gress TM</searchLink>; Department of Gastroenterology, University Hospital of Giessen and Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Greenhalf+W%22">Greenhalf W</searchLink>; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Sharp+L%22">Sharp L</searchLink>; National Cancer Registry Ireland and HRB Clinical Research Facility, University College Cork, Cork, Ireland.; 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