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Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy.

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Title: Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy.
Authors: Wang Y; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA. Electronic address: yulei.wang1@gmail.com., Guan Y; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA., Abbas AR; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA., Sano Y; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Jain S; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA., Lu S; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA., Hamidi H; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA., Koeppen H; Department of Research Pathology, Genentech, Inc., South San Francisco, CA, USA., Azuma Y; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Kayukawa Y; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Shinozuka J; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Pochiraju A; Product Development, Roche, South San Francisco, CA, USA., Webster JD; Department of Research Pathology, Genentech, Inc., South San Francisco, CA, USA., Rieder N; Roche Diagnostics GmbH, Mannheim, Germany., Dietmann G; Roche Diagnostics GmbH, Mannheim, Germany., Cannarile M; Roche Diagnostics GmbH, Mannheim, Germany., Cotter C; Product Development, Roche, South San Francisco, CA, USA., Hack SP; Product Development, Roche, South San Francisco, CA, USA., Cha E; Product Development, Roche, South San Francisco, CA, USA., Ishiguro T; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan., Llovet JM; Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Translational Research in Hepatic Oncology, Liver Unit, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain., Zhu AX; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA; Jiahui International Cancer Center, Jiahui Health, Shanghai, China., Finn RS; Jonsson Comprehensive Cancer Center, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Dec 16; Vol. 6 (12), pp. 102473. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA. Electronic address: yulei.wang1@gmail.com.<br /><searchLink fieldCode="AU" term="%22Guan+Y%22">Guan Y</searchLink>; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Abbas+AR%22">Abbas AR</searchLink>; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sano+Y%22">Sano Y</searchLink>; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Jain+S%22">Jain S</searchLink>; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hamidi+H%22">Hamidi H</searchLink>; Department of Translational Medicine, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Koeppen+H%22">Koeppen H</searchLink>; Department of Research Pathology, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Azuma+Y%22">Azuma Y</searchLink>; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kayukawa+Y%22">Kayukawa Y</searchLink>; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Shinozuka+J%22">Shinozuka J</searchLink>; Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Pochiraju+A%22">Pochiraju A</searchLink>; Product Development, Roche, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Webster+JD%22">Webster JD</searchLink>; Department of Research Pathology, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rieder+N%22">Rieder N</searchLink>; Roche Diagnostics GmbH, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Dietmann+G%22">Dietmann G</searchLink>; Roche Diagnostics GmbH, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Cannarile+M%22">Cannarile M</searchLink>; Roche Diagnostics GmbH, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Cotter+C%22">Cotter C</searchLink>; Product Development, Roche, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hack+SP%22">Hack SP</searchLink>; Product Development, Roche, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cha+E%22">Cha E</searchLink>; Product Development, Roche, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ishiguro+T%22">Ishiguro T</searchLink>; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Llovet+JM%22">Llovet JM</searchLink>; Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Translational Research in Hepatic Oncology, Liver Unit, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Zhu+AX%22">Zhu AX</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA; Jiahui International Cancer Center, Jiahui Health, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Finn+RS%22">Finn RS</searchLink>; Jonsson Comprehensive Cancer Center, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2025 Dec 16; Vol. 6 (12), pp. 102473. <i>Date of Electronic Publication: </i>2025 Nov 28.
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