ERK-mTOR crosstalk suppresses autophagy and upregulates proteasomal degradation pathway to confer chronic myeloid leukemia cells resistant to imatinib.

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Title: ERK-mTOR crosstalk suppresses autophagy and upregulates proteasomal degradation pathway to confer chronic myeloid leukemia cells resistant to imatinib.
Authors: Roy R; Department of Life Sciences, Presidency University, Kolkata, India., Paul T; Department of Life Sciences, Presidency University, Kolkata, India., Das PK; Department of Life Sciences, Presidency University, Kolkata, India., Sinha S; Department of Life Sciences, Presidency University, Kolkata, India., Ray SS; Institute of Hematology & Transfusion Medicine, Medical College Kolkata, India., Bhattacharyya M; Institute of Hematology & Transfusion Medicine, Medical College Kolkata, India., Biswas N; Department of Life Sciences, Presidency University, Kolkata, India. Electronic address: nabendu.dbs@presiuniv.ac.in.
Source: Experimental hematology [Exp Hematol] 2026 Feb; Vol. 154, pp. 105330. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Inc Country of Publication: Netherlands NLM ID: 0402313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2399 (Electronic) Linking ISSN: 0301472X NLM ISO Abbreviation: Exp Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-2399
DOI:10.1016/j.exphem.2025.105330